Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis

Launched by QATAR UNIVERSITY · Dec 2, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different types of fluids, Normal Saline (NS) and Lactated Ringer's (LR), on patients with acute pancreatitis, a condition where the pancreas becomes inflamed and can cause severe pain and other serious issues. The goal is to find out which fluid works better for helping patients recover. Researchers will review existing studies that compare these two fluids and will analyze their findings to provide clearer answers. The main aspect they will look at is whether patients develop "Systemic Inflammatory Response Syndrome" (SIRS) within the first 24 hours of treatment, which is a serious condition that can occur with pancreatitis.

To participate in this trial, individuals must have been diagnosed with acute pancreatitis and should be part of studies that directly compare NS and LR. Importantly, only studies involving adult patients will be included, while those involving children, animals, or laboratory studies will not. Participants can expect that their data will be carefully reviewed and analyzed to determine the best fluid for treatment, helping to improve care for future patients with this condition. If you are considering joining the trial, know that it aims to provide clearer answers to a question that has been debated in the medical community for some time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • RCTs and observational studies that compared NS vs LR in AP patients.
• • Studies reviewed must report data as effect estimates or provide raw data sufficient to calculate effect estimates.
• Exclusion Criteria:
• • Studies involving animal studies, pediatric patient populations, and cell lines will be excluded.
• • All studies will be reviewed in full form by each author to determine eligibility. In case of disagreement, determination of inclusion will be reached via consensus.