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Search / Trial NCT05638893

Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients

Launched by TANTA UNIVERSITY · Nov 28, 2022

Trial Information

Current as of January 21, 2025

Completed

Keywords

Metformin Knee Osteoarthritis

ClinConnect Summary

Metformin is a safe, well-tolerated oral biguanide widely used as first-line therapy for type 2 diabetes for over 50 years. In addition to its glucose-lowering effects, metformin modulates inflammatory and metabolic factors resulting in weight loss and reduced inflammation and plasma lipids. Data from animal studies suggest that metformin could limit OA development and progression, possibly through activating AMPK.

Retrospective cohort study of participants with OA and type 2 diabetes reported that patients receiving a combination of cyclooxygenase-2 inhibitors and metformin therapy had a ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients have symptomatic and radiological evidence of OA in one or both knee joints.
  • Age ≥ 45 years.
  • Both obese male and female will be included (BMI ≥ 30 kg/m²).
  • Exclusion Criteria:
  • Patients with inflammatory rheumatic diseases, crystal deposition arthritis or infection-induced OA.
  • Patient with hypertension or diabetes mellitus.
  • Patient with hepatic or renal impairment.
  • Patients who have active peptic ulcer.
  • Patients with positive malignancy.
  • Steroid injection into the affected knee joint within 3 months of recruitment for the study.
  • Pregnant or lactating female patients.

Trial Officials

Sahar M El-Haggar, Professor

Study Chair

Tanta University

Amal M El-Barbary, Professor

Study Chair

Tanta University

About Tanta University

Tanta University is a prestigious academic institution located in Egypt, dedicated to advancing medical research and education. As a clinical trial sponsor, Tanta University leverages its extensive resources and expertise to conduct innovative research initiatives aimed at improving health outcomes. The university collaborates with a network of healthcare professionals, researchers, and institutions to facilitate rigorous clinical trials across various medical disciplines. Committed to ethical standards and scientific integrity, Tanta University strives to contribute to the global body of knowledge while fostering the next generation of medical professionals.

Locations

Tanta, Gharbia, Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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