The Treatment of Adrenal Crisis With Inhaled Prednisolone
Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · Nov 24, 2022
Trial Information
Current as of January 13, 2025
Unknown status
Keywords
ClinConnect Summary
The prevalence of adrenal insufficiency is approximately 30-50 individuals per 100.0001. Patients with adrenal insufficiency rely on glucocorticoid substitution therapy (hydrocortisone or cortisone acetate). In case of an acute stressful situation, e.g. illness, trauma, or psychological stress, the standard substitution dose falls short and patients need to increase their glucocorticoid dose to prevent a cortisol deficiency which could ultimately lead to an adrenal crisis. The incidence of an adrenal crisis is about 5-10 cases per year 100 patient-years and is characterized by hypotension, ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age: 18 - 75 years
- • Woman who use reliable contraceptives or with a negative pregnancy test
- • Equal sex distribution
- Exclusion Criteria:
- • Heart failure
- • Known liver or kidney disease
- • Dependency on glucocorticoids
- • Adrenogenital syndrome
- • Infectious disease
- • Uncontrolled hypertension defined as a blood pressure \> 180/110 mmHg
- • Pregnancy or breastfeeding
- • Use of medication that interferes with cytochrome P450 (e.g. carbamazepine)
About University Medical Center Groningen
University Medical Center Groningen (UMCG) is a leading academic medical center in the Netherlands, renowned for its commitment to innovative research, high-quality patient care, and extensive education in the medical field. As a prominent sponsor of clinical trials, UMCG leverages its multidisciplinary expertise and state-of-the-art facilities to advance medical knowledge and improve therapeutic outcomes. The center fosters collaboration among researchers, healthcare professionals, and industry partners, aiming to translate scientific discoveries into effective treatments that enhance patient health and well-being. With a focus on ethical standards and regulatory compliance, UMCG is dedicated to conducting clinical trials that contribute to the advancement of medicine and the betterment of society.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Groningen, , Netherlands
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
Similar Trials