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The Treatment of Adrenal Crisis With Inhaled Prednisolone

Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · Nov 24, 2022

Trial Information

Current as of January 13, 2025

Unknown status

Keywords

ClinConnect Summary

The prevalence of adrenal insufficiency is approximately 30-50 individuals per 100.0001. Patients with adrenal insufficiency rely on glucocorticoid substitution therapy (hydrocortisone or cortisone acetate). In case of an acute stressful situation, e.g. illness, trauma, or psychological stress, the standard substitution dose falls short and patients need to increase their glucocorticoid dose to prevent a cortisol deficiency which could ultimately lead to an adrenal crisis. The incidence of an adrenal crisis is about 5-10 cases per year 100 patient-years and is characterized by hypotension, ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Age: 18 - 75 years
  • Woman who use reliable contraceptives or with a negative pregnancy test
  • Equal sex distribution
  • Exclusion Criteria:
  • Heart failure
  • Known liver or kidney disease
  • Dependency on glucocorticoids
  • Adrenogenital syndrome
  • Infectious disease
  • Uncontrolled hypertension defined as a blood pressure \> 180/110 mmHg
  • Pregnancy or breastfeeding
  • Use of medication that interferes with cytochrome P450 (e.g. carbamazepine)

About University Medical Center Groningen

University Medical Center Groningen (UMCG) is a leading academic medical center in the Netherlands, renowned for its commitment to innovative research, high-quality patient care, and extensive education in the medical field. As a prominent sponsor of clinical trials, UMCG leverages its multidisciplinary expertise and state-of-the-art facilities to advance medical knowledge and improve therapeutic outcomes. The center fosters collaboration among researchers, healthcare professionals, and industry partners, aiming to translate scientific discoveries into effective treatments that enhance patient health and well-being. With a focus on ethical standards and regulatory compliance, UMCG is dedicated to conducting clinical trials that contribute to the advancement of medicine and the betterment of society.

Locations

Groningen, , Netherlands

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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