The Treatment of Adrenal Crisis With Inhaled Prednisolone

Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · Nov 24, 2022

Keywords

ClinConnect Summary

The prevalence of adrenal insufficiency is approximately 30-50 individuals per 100.0001. Patients with adrenal insufficiency rely on glucocorticoid substitution therapy (hydrocortisone or cortisone acetate). In case of an acute stressful situation, e.g. illness, trauma, or psychological stress, the standard substitution dose falls short and patients need to increase their glucocorticoid dose to prevent a cortisol deficiency which could ultimately lead to an adrenal crisis. The incidence of an adrenal crisis is about 5-10 cases per year 100 patient-years and is characterized by hypotension, ...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age: 18 - 75 years
• • Woman who use reliable contraceptives or with a negative pregnancy test
• • Equal sex distribution
• Exclusion Criteria:
• • Heart failure
• • Known liver or kidney disease
• • Dependency on glucocorticoids
• • Adrenogenital syndrome
• • Infectious disease
• • Uncontrolled hypertension defined as a blood pressure \> 180/110 mmHg
• • Pregnancy or breastfeeding
• • Use of medication that interferes with cytochrome P450 (e.g. carbamazepine)