TMS as a Tool for the Evaluation of Neuromodulatory Effects of Transcutaneous Vagus Nerve Stimulation

Launched by UNIVERSITY GHENT · Dec 5, 2022

Keywords

ClinConnect Summary

In the past two decades, vagus nerve stimulation (VNS)has become a valuable treatment option for patients with refractory epilepsy. However, VNS requires a surgical procedure associated with potential side effects. Therefore, the development of non-invasive devices that selectively target the vagus nerve fibers with a low risk profile has gained interest. Transcutaneous auricular VNS (tVNS) is such a non-invasive neurostimulation modality that targets the cutaneous receptive field of the auricular branch of the vagus nerve located in the outer ear. Up to date, tVNS has been investigated as ...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • estimated IQ \> 70
• • healthy volunteer, taken from anamensis, clinical neurological examination and clinical estimation of researcher
• • no history of central neurological condition
• • no treatment with neurotropic drugs
• • TMS safety screening questionnaire
• • ICF signed
• Exclusion Criteria:
• • intracranial metal objects/materials (excl teeth fillings): vascular clips, shrapnell electrodes below stimulation area
• • pacemaker, implanted defibrillator, permanent medication pump, cochlear implant or deep brain stimulation (DBS)

Trial Officials