Effect of Different Doses of Dexmedetomidine on Cerebral Oxygen Saturation and Postoperative Anxiety in Elderly Patients

Launched by THE FIRST HOSPITAL OF QINHUANGDAO · Dec 6, 2022

Keywords

ClinConnect Summary

A total of 105 patients who were admitted to The First Hospital of Qinhuangdao for laparoscopic surgery and divided into control group (group C), dexmedetomidine doses of 0.2 μg/kg (group D1), dexmedetomidine doses of 0.5 μg/kg (group D2).

105 patients were randomized equally into 3 groups. 35 cases in each group. Group C received general anesthesia without dexmedetomidine, groups D1 received general anesthesia with intravenous pump of 0. 2μg/kg/h dexmedetomidine, groups D2 received general anesthesia with intravenous pump of 0. 5μg/kg/h dexmedetomidine.SBP(Systolic Blood Pressure),DP(Dias...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 65 years or older who underwent elective laparoscopic surgery under general anesthesia
• • BMI less than 30 kg/m2
• • American Society of Anesthesiologists (ASA) grades I-III
• • The score of Mini Mental state examination≥24
• Exclusion Criteria:
• • Patients with heart, lung and other vital organ disorders
• • The score of Mini Mental state examination≤23
• • Preoperative psychiatric disorders or long-term use of drugs affecting the psychiatric system
• • Have severe visual, hearing, speech impairment or other inability to communicate with the visitor
• • Refuse to sign informed consent
• • known preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (\<50 beats per min \[bpm\]), or second-degree or greater atrioventricular block without pacemaker

Trial Officials