Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting

Launched by TANTA UNIVERSITY · Dec 6, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring how effective two medications, pregabalin and dexmedetomidine, are in treating a condition called delirium in elderly patients after they have heart surgery, specifically Coronary Artery Bypass Grafting (CABG). Delirium is a sudden change in mental status that can occur after surgery, and this study aims to see which of the two medications helps patients recover faster and have fewer long-lasting effects.

To participate in this trial, you need to be at least 65 years old and scheduled for CABG surgery. The study is looking for patients who are otherwise healthy but may have developed delirium after their surgery. However, if you have a history of severe heart issues, psychiatric problems, or certain other medical conditions, you may not be eligible. If you do join the study, you can expect to receive either pregabalin or dexmedetomidine and be monitored closely for changes in your condition. This research could help improve care for older adults undergoing heart surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • CABG patients ≥ 65 years of age both genders American Society of Anesthesiologists (ASA) physical status classification II or III planned for fast track developed postoperative delirium (POD).
• Exclusion Criteria:
• • Patients who had history of psychiatric diseases; inability to communicate;
• • previous history of POD; preoperative sick sinus syndrome, allergy/sensitivity to pregabalin or dexmedetomidine, severe bradycardia (heart rate \<50 beat per minute), second-degree or above atrioventricular block without pacemaker; severe hepatic or renal insufficiency.
• • Previous cardiac or thoracic surgery, known diagnosis of depression or other major psychiatric diseases, cognitive impairment or inability to cooperate with the study, renal insufficiency, and history of substance abuse.