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Search / Trial NCT05640479

Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery

Launched by TANTA UNIVERSITY · Dec 6, 2022

Trial Information

Current as of January 14, 2025

Completed

Keywords

ClinConnect Summary

This clinical trial is studying how effective two medications, pregabalin and dexmedetomidine, are in preventing delirium, which is a sudden change in mental status, in elderly patients after they have heart surgery. Delirium can cause confusion and is more common in older adults following surgery. The goal is to see which medication works better at reducing the chances of developing delirium and how long it lasts if it does occur.

To be eligible for this study, participants need to be at least 65 years old and scheduled for heart surgery. However, those with certain conditions, like a history of severe heart problems, psychiatric issues, or those unable to communicate, cannot take part. If someone joins the trial, they will receive either pregabalin or dexmedetomidine before and after their surgery. This research is important because it could help improve care for older patients undergoing heart surgery by finding better ways to prevent delirium.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • ≥ 65 years of age both genders American Society of Anesthesiologists (ASA) physical status classification II or III scheduled for cardiac surgery.
  • Exclusion Criteria:
  • Patients who had history of psychiatric diseases; inability to communicate; previous history of POD; preoperative sick sinus syndrome.
  • Allergy/sensitivity to pregabalin or dexmedetomidine.
  • Severe bradycardia (heart rate \<50 beat per minute).
  • Second-degree or above atrioventricular block without pacemaker.
  • Severe hepatic or renal insufficiency.
  • Previous cardiac or thoracic surgery.
  • Known diagnosis of depression or other major psychiatric diseases.
  • Cognitive impairment or inability to cooperate with the study.
  • Renal insufficiency, and history of substance abuse.

Trial Officials

Doha M Bakr, MD

Principal Investigator

Lecturer of Anesthesiology

Osama M Rehab, MD

Principal Investigator

Lecturer of Anesthesiology

About Tanta University

Tanta University is a prestigious academic institution located in Egypt, dedicated to advancing medical research and education. As a clinical trial sponsor, Tanta University leverages its extensive resources and expertise to conduct innovative research initiatives aimed at improving health outcomes. The university collaborates with a network of healthcare professionals, researchers, and institutions to facilitate rigorous clinical trials across various medical disciplines. Committed to ethical standards and scientific integrity, Tanta University strives to contribute to the global body of knowledge while fostering the next generation of medical professionals.

Locations

Tanta, Gharbia, Egypt

Tanta, Elgharbiaa, Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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