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Biopsy Versus Resection in Elderly Glioblastoma Patients. A Prospective Cohort Study.

Launched by ERASMUS MEDICAL CENTER · Nov 29, 2022

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Trial Information

Current as of February 05, 2025

Not yet recruiting

Keywords

Glioblastoma High Grade Glioma Surgical Management Biopsy Resection

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • 1. Age ≥70 years
  • • 2. Tumor diagnosed as glioblastoma on MRI with distinct ring-like pattern of contrast enhancement with thick irregular walls and a core area reduced signal suggestive of tumor necrosis as assessed by the surgeon.
  • • 3. Karnofsky Performance Score (KPS) ≥70
  • • 4. Written Informed consent
  • Exclusion Criteria:
  • • 1. Tumors of the cerebellum, brain stem or midline
  • • 2. Multifocal contrast enhancing lesions
  • • 3. Substantial non-contrast enhancing tumor areas suggesting low grade gliomas with malignant transformation
  • • 4. Medical reasons precluding MRI (e.g. pacemaker)
  • • 5. Inability to give consent as assessed by neurosurgeon (e.g. language barrier)
  • • 6. Severe aphasia prohibiting neurolinguistic testing and comprehension of informed consent
  • • 7. Previous brain tumor surgery
  • • 8. Previous low-grade glioma
  • • 9. Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin.

Trial Officials

Arnaud J.P.E. Vincent, Prof. Dr.

Principal Investigator

Erasmus MC, department of neurosurgery

About Erasmus Medical Center

Erasmus Medical Center, located in Rotterdam, Netherlands, is a leading academic medical center renowned for its commitment to advancing healthcare through innovative research and clinical trials. As a prominent institution within the Erasmus University Rotterdam, the center integrates cutting-edge scientific inquiry with comprehensive patient care, focusing on a wide range of medical specialties. With a strong emphasis on multidisciplinary collaboration, Erasmus Medical Center aims to translate research findings into tangible clinical applications, enhancing treatment options and improving patient outcomes. The institution is dedicated to conducting ethical and rigorous clinical trials that contribute to the global body of medical knowledge and foster advancements in personalized medicine.

Locations

Rotterdam, , Netherlands

Maastricht, , Netherlands

Enschede, , Netherlands

Den Haag, , Netherlands

Rotterdam, Zuid Holland, Netherlands

Alkmaar, , Netherlands

Tilburg, , Netherlands

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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