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Research on Optimal Strategy of Hypoglycemic Therapy for Cirrhosis With Diabetes

Launched by HUASHAN HOSPITAL · Nov 29, 2022

Trial Information

Current as of January 13, 2025

Recruiting

Keywords

Liver Cirrhosis Diabetes Time In Range Insulin Intensive Therapy New Combination Therapy

ClinConnect Summary

This clinical trial is studying new ways to manage blood sugar levels in patients who have both liver cirrhosis and diabetes. Poorly controlled blood sugar can worsen health outcomes in these patients, so finding a better treatment strategy is very important. The trial is testing a combination of medications, including metformin and Ryzodeg, to see if they can help control blood sugar levels without causing dangerous drops in blood sugar (hypoglycemia) or other serious side effects. Researchers will compare this new treatment plan with the traditional approach that relies heavily on insulin.

To participate in the trial, individuals must be between 18 and 70 years old, have liver cirrhosis, and have high blood sugar levels. However, those with certain health issues, such as severe heart problems or advanced liver cancer, will not be eligible. Participants can expect to receive careful monitoring throughout the study to ensure their safety and track how well the treatment works. This trial aims to provide valuable information that could lead to improved guidelines for treating diabetes in patients with liver cirrhosis, ultimately helping to enhance their overall health and quality of life.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Liver cirrhosis
  • Age 18-70 years
  • Patients with elevated blood sugar who meet the diabetes standard or have been treated with hypoglycemic drugs
  • random finger or venous serum blood glucose more than 14 mmol/L
  • Exclusion Criteria:
  • Those unwilling to participate or unable to cooperate;
  • Child-pugh score is greater than 12;
  • Glomerular filtration rate\<60ml/min/1.73m2;
  • Patients with cardiac insufficiency;
  • Patients with asymptomatic hypoglycemia;
  • Pregnant patients were excluded;
  • Patients with advanced liver cancer;
  • Blood pressure is less than 90/60mmHg;
  • Chronic liver disease plus acute or subacute liver failure;
  • Patients with drug induced blood glucose disorder, such as glucocorticoids, contraceptives, etc;
  • fingertip oxygen saturation less than 95% without oxygen inhalation;
  • Autoimmune liver cirrhosis is currently taking hormone.
  • Type 1 diabetes.
  • Pancreatogenic diabetes, such as primary hemochromatosis, hepatolenticular degeneration, alcoholic pancreatitis, autoimmune diseases involving the pancreas, etc.

Trial Officials

Xiaolong Zhao, PhD

Study Chair

Shanghai Public Health Clinical Center

About Huashan Hospital

Huashan Hospital, affiliated with Fudan University in Shanghai, is a leading medical institution renowned for its commitment to innovative research and high-quality patient care. As a prominent clinical trial sponsor, Huashan Hospital leverages its extensive expertise in various medical disciplines to advance the development of new therapies and treatment modalities. The hospital's state-of-the-art facilities and multidisciplinary teams facilitate rigorous clinical investigations, ensuring adherence to ethical standards and regulatory compliance. With a focus on improving patient outcomes, Huashan Hospital actively collaborates with academic and industry partners to drive forward-thinking research initiatives that address critical healthcare challenges.

Locations

Shanghai, Shanghai, China

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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