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Search / Trial NCT05641636

Cardiovascular Disorders and Risk Factors in Childhood Cranial and Craniospinal Tumors Survivors

Launched by I.M. SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY · Dec 6, 2022

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Trial Information

Current as of January 16, 2025

Completed

Keywords

Brain Tumors In Children Risk Of Cardiovascular Disease Radiation Therapy Dyslipidemia Endothelial Dysfunction Cardiopulmonary Testing

ClinConnect Summary

Cardiovascular disease, after recurrence of the original cancer and development of second primary cancers, has been reported to be the leading cause of premature mortality among long-term childhood cancer survivors. Childhood cancer survivors after chemotherapy and radiotherapy for cranial and craniospinal tumors are at increased risk of transient ischemic attack, ischemic stroke. The mechanisms of vascular damage are not well understood. Preventive measures are not developed.

The purpose of my research is to study to adverse cardiovascular disorder and risks factors in childhood cranial a...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • radiation and chemotherapy for cranial and craniospinal tumors in childhood or adolescence
  • • completion of the therapy at least one year before enrollment
  • • signed informed consent
  • • there were three separate types of informed consent - for adults, for minors and for their parents
  • • minors were signing informed consent in the presence of their parents.
  • Exclusion Criteria:
  • • standard contraindications to exercise testing
  • • anemia, pregnancy
  • • psychiatric disease
  • • alcohol or drug abuse
  • • active malignancy
  • • acute infection

About I.M. Sechenov First Moscow State Medical University

i.m. Sechenov First Moscow State Medical University is a prestigious institution dedicated to advancing medical education, research, and clinical practice. As a leading center for medical innovation in Russia, the university fosters a collaborative environment for scientific inquiry and the development of novel therapies. With a commitment to high-quality clinical trials, i.m. Sechenov aims to contribute significantly to the global biomedical landscape by evaluating new treatments and improving patient care through rigorous research methodologies and ethical standards.

Locations

Moscow, , Russian Federation

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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