Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis

Launched by MEDICAL UNIVERSITY OF GRAZ · Dec 5, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a treatment called isolated ultrafiltration in patients with end-stage kidney disease who are undergoing hemodialysis. Hemodialysis helps filter waste from the blood, but some patients experience a drop in blood pressure during the treatment, which can lead to serious health issues. The goal of this study is to see if isolated ultrafiltration can help manage these blood pressure drops and improve overall health outcomes for patients.

To participate in the trial, you need to be at least 18 years old and currently receiving hemodialysis for end-stage kidney disease. It's important that you have been stable in your treatment for at least a month and have had significant weight gain between dialysis sessions. Participants will be closely monitored during the trial, and you’ll receive detailed information about what to expect. If you're interested in joining or learning more, please talk to your healthcare provider to see if you might qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Written consent of the participant after being informed
• • At least 18 years of age
• • End stage kidney disease patient undergoing hemodialysis
• • Dry weight stable for a minimum of one month
• • Interdialytic weight gain of \>2 liters in the short interdialytic interval
• Exclusion Criteria:
• • No informed consent was obtained
• • Patients with a pacemaker or implanted medical device that prevents compliance with study regulations
• • Patients treated with hemodiafiltration
• • Patients treated with medium cut-off membranes (Theranova, Baxter)
• • Patients with recurrent severe hyperkalemia after the short interdialytic interval (K+ concentration \> 6.0 mmol/L, requiring more than 2 hours of dialysis to ameliorate the post-dialytic shift from other compartments.
• • Women of childbearing age not using contraception