REVOLUTION Surgery (REVOLUTION Surgery)

Launched by UNIVERSITY OF EDINBURGH · Nov 29, 2022

Keywords

ClinConnect Summary

The REVOLUTION Surgery trial is studying a condition called cachexia, which affects some people with cancer, leading to weight loss, muscle wasting, and fatigue. This trial aims to gather detailed information from patients who are at risk of cachexia, particularly those with oesophageal, gastric, pancreatic, or colorectal cancers who are scheduled for surgery. By looking at various factors like body composition, physical activity, quality of life, and the body's immune response to cancer, the researchers hope to gain a better understanding of how cachexia impacts patients both before and after surgery.

To participate, you need to be at least 18 years old and have a confirmed diagnosis of cancer that requires surgical treatment. There will also be a small group of healthy individuals, undergoing surgery for a non-cancer condition, included for comparison. Participants will have their height and weight measured, answer questions about their quality of life, and undergo some blood tests and imaging studies. After surgery, cancer patients will return for follow-up appointments to repeat these assessments over the course of a year. This study is important as it aims to create a complete picture of how cachexia affects surgical patients, helping to improve care and outcomes for those facing cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Inclusion Criteria (Cancer Resection)
• • Patients with cancer (Clinical, histological, cytological or radiological evidence) planned for surgical resection of a malignancy of the oesophagus, stomach, pancreas, colon, or rectum
• • Aged 18-years and over
• • Able to give written informed consent
• • Inclusion Criteria (Healthy Controls)
• • Patients identified at surgical clinic as being planned for an open abdominal operation for a non-inflammatory, benign condition (e.g. donor nephrectomy)
• • Aged 18-years and over
• • Able to give written informed consent
• Exclusion Criteria:
• • Any concomitant medical or psychiatric problems which, in the opinion of the investigator, would increase the risk of complication for the participant and/or investigator
• • Presence of a concomitant inflammatory (e.g., rheumatoid arthritis, inflammatory bowel disease) or muscle wasting condition other than cancer
• • Participants who are pregnant, suffer from claustrophobia or with implanted medical devices (e.g., cardiac pacemaker, metallic foreign bodies, aneurysm clip) would not be able to undergo the additional multiparametric magnetic resonance imaging (MRI)

Trial Officials