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Search / Trial NCT05642832

Feasibility of Reducing Respiratory Drive Using the Through-flow System

Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Nov 29, 2022

Trial Information

Current as of January 17, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying a new system called Throughflow, which aims to help patients with breathing difficulties caused by lung or diaphragm injuries. These injuries can happen when patients are on mechanical ventilation, a machine that helps them breathe. The Throughflow system is designed to make it easier for the body to breathe by reducing the amount of work the lungs and diaphragm have to do. This could potentially lower the risk of further injury and improve recovery.

To participate in this trial, patients must be between the ages of 65 and 74 and currently on mechanical ventilation due to serious breathing problems, specifically if they have low oxygen levels and visible issues in both lungs on scans. Candidates should not have certain medical conditions that would prevent them from safely participating, like recent surgery in the stomach area or specific brain injuries. If eligible, participants will be monitored closely while using the Throughflow system, and the research team will evaluate how well it works in reducing breathing demands.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • PaO2/FiO2 less than or equal to 300 at time of screening
  • Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation
  • Bilateral airspace opacities on chest radiograph or chest CT scan
  • Exclusion Criteria:
  • Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal/gastric varices)
  • Intubation for traumatic brain injury or stroke
  • Intracranial hypertension (suspected or diagnosed by medical team)
  • Anticipated liberation from mechanical ventilation within 24 hours

Trial Officials

Ewan Goligher, MD, PhD

Principal Investigator

University Health Network, Toronto

Lorenzo Del Sorbo

Principal Investigator

University Health Network, Toronto

About University Health Network, Toronto

University Health Network (UHN), based in Toronto, is a leading academic health sciences center dedicated to advancing patient care through innovative research and education. As a prominent sponsor of clinical trials, UHN integrates cutting-edge scientific discoveries with clinical practice, facilitating the development of new therapies and treatment modalities. With a commitment to improving health outcomes, UHN collaborates with a diverse network of researchers, healthcare professionals, and industry partners, fostering an environment that prioritizes patient safety and ethical standards in clinical research. Through its extensive resources and expertise, UHN plays a pivotal role in transforming healthcare and enhancing the quality of life for patients both locally and globally.

Locations

Toronto, Ontario, Canada

Toronto, Ontario, Canada

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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