Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors

Launched by NORTHWELL HEALTH · Dec 1, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring how well a special heart monitor, called the Medtronic LINQ-2 insertable cardiac monitor, can help detect heart rhythm problems (known as arrhythmias) in patients starting treatment with a medication called Bruton Tyrosine Kinase (BTK) inhibitors. These medications are often used for certain types of blood cancers like chronic lymphocytic leukemia. The study aims to find out how many patients experience new heart rhythm issues while on this treatment, and what actions are taken when these issues are detected.

To be eligible for the trial, participants must be at least 18 years old and starting a BTK inhibitor without a recent history of heart rhythm problems. They should also be willing to have the heart monitor implanted for at least 24 hours to track their heart activity. Participants can expect regular remote monitoring to check for any new arrhythmias during their treatment. It's important to note that individuals with certain health issues, such as recent heart attacks or strokes, or those already using specific heart devices, cannot take part in the study. Overall, this trial aims to enhance our understanding of heart health in patients receiving BTK inhibitors, which could lead to better care and management of any arising heart problems.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \>18yo
• • Willing to sign and date consent form,
• • Willing to be remotely monitored
• • Initiating BTK inhibitor for approved condition (i.e. CLL, Waldenstrom's, etc)
• • Willing to have Medtronic cardiac monitor inserted to allow at minimum 24 hours continuous monitoring prior to initiating BTK inhibitor
• Exclusion Criteria:
• • Documented AF/VA in past 12 months
• • Cerebral Vascular Accident (CVA) or Transient Ischemic Attack (TIA) in past year
• • Has current implanted pulse generator, defibrillator, pacemaker, or resynchronization device
• • heart surgery within past 90 days
• • Myocardial Infarction within past 90 days
• • Patient is taking an anti-arrhythmic or anticoagulant
• • has concomitant condition that precludes safe participation in study (substance abuse, etc)
• • Enrollment in separate study that could confound results of this study

Trial Officials