Factors Affecting Timing of Hypothyroidism Following Radioactive Iodine Therapy Patients With Graves Disease
Launched by ASSIUT UNIVERSITY · Dec 7, 2022
Trial Information
Current as of January 13, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the factors that may influence how quickly some patients develop hypothyroidism (an underactive thyroid) after receiving radioactive iodine therapy for Graves' disease, a condition that causes an overactive thyroid. Researchers want to understand why some patients experience early symptoms of hypothyroidism following this treatment, which is often used to manage Graves' disease.
To be eligible for this study, participants should be adults aged 18 to 80 who have been treated with radioactive iodine for Graves' disease at least a year ago. They should also have specific thyroid hormone levels, including low thyroid-stimulating hormone (TSH) and high levels of other thyroid hormones. Participants will undergo assessments and follow-ups for about six months. The information gathered will help doctors better understand how to manage thyroid health after treatment for Graves' disease.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Graves' disease patients after one year of RAI therapy .
- • 2. Suppressed serum thyrotropin (TSH) \<0.55 µU/ml , elevated serum free triiodothyronine (FT3) \> 6.5 pmol/L , free thyroxin FT4 \>22.7 pmol/L .
- Exclusion Criteria:
- • 1. Patients with other causes of hyperthyroidism , such as toxic multinodular goiter and single toxic adenoma
- • 2. Thyroid cancer
- • 3. Recurrent GD
- • 4. Previous Thyroid surgery
- • 5. Patients can't complete the follow -up within 6 months.
Trial Officials
Hemat A Mahmoud, M.D
Study Director
Lecturer
Hanan G Mostafa, M.D
Study Chair
Professor
About Assiut University
Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Assiut, , Egypt
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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