Effects of Isolated LBBB on Maximal Functional Capacity

Launched by FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL CLÍNICO DE VALENCIA · Dec 7, 2022

Keywords

ClinConnect Summary

Left bundle branch block (LBBB) has been commonly associated with adverse cardiovascular (CV) events, but the effect of an isolated LBBB on maximal functional capacity is not well characterized.

The main objective of the study is to evaluate the effect of LBBB on maximum functional capacity (objectively evaluated by the maximum oxygen consumption -VO2max- at peak exercise in a cardiopulmonary stress test -CPET-) in subjects with LBBB without known cardiovascular disease and compare these data with controls without LBBB.

This is a prospective study that will be carried out in a single cent...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult \>18 years old
• • ECG criteria of left bundle branch block (for controls without left bundle branch block )
• • Provide informed consent
• Exclusion Criteria:
• • Inability to perform a maximal baseline exercise test;
• • Structural heart disease, valve heart disease or diastolic dysfunction estimated by two-dimensional echocardiography;
• • Previous ischemic heart disease, heart failure, myocardiopathy or myocarditis
• • Effort angina during cardiopulmonary exercise testing (CPET);
• • Any moderate pulmonary disease;
• • Anaemia
• • Left ventricular ejection fraction \< 55%.

Trial Officials