Impact of Dietary Fiber Supplementation on Colonic Mucosal Microbiome

Launched by OHSU KNIGHT CANCER INSTITUTE · Dec 1, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how taking daily fiber supplements might change the microorganisms in the colon, known as the mucosal microbiome. These tiny organisms play a crucial role in our health, and certain types can be linked to the development of polyps, which are abnormal growths that can sometimes lead to colon cancer. By adding more fiber to the diet, researchers hope to see if it can help prevent these precancerous polyps from forming in the first place.

To participate in this trial, you need to be at least 18 years old and be willing to sign a consent form. The study is open to anyone who has issues like hemorrhoids or anal fissures but does not have serious conditions like cancer or inflammatory bowel disease. If you join the study, you will be monitored while taking the fiber supplements, and the team will check how your gut health is affected. It's an exciting opportunity to contribute to research that could help prevent colon cancer in the future!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>= 18 years
• • Ability to understand and the willingness to sign a written informed consent document
• • Patients who present with a chief complaint of a benign anorectal pathology including hemorrhoids, anal fissures, and anal fistulas without underlying conditions such as cancer or Crohn's disease or are undergoing a standard of care colonoscopy procedure
• Exclusion Criteria:
• • Patients with an active malignancy, Crohn's disease, ulcerative colitis, and immunosuppressed patients.
• • Patients with hereditary colon cancer syndrome including Lynch syndrome or Familial Adenomatous Polyposis (FAP)
• • Patients with a prior history of total or partial colon resection.
• • Colorectal pathology such as polyps or cancer

Trial Officials