Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position

Launched by ASAN MEDICAL CENTER · Dec 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different anesthesia medications, remimazolam and propofol, on patients undergoing major spinal surgery. The main goal is to see which medication is safer for blood pressure stability during surgery, especially since many surgeries can cause a drop in blood pressure, which can lead to serious complications after the surgery. Remimazolam is a newer medication that works quickly and is expected to have fewer negative effects on blood pressure compared to the more commonly used propofol.

To participate in this trial, patients should be between 19 and 80 years old and scheduled for major spinal surgery. They should be in good health overall, without serious heart issues or other conditions that could complicate their care. Participants can expect to receive either remimazolam or propofol during their surgery, and the research team will closely monitor their blood pressure and overall health throughout the procedure. This trial is important because finding a safer anesthesia option could help reduce the risks associated with major surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ASA physical status: 1-3
• • age: 19-80 years
• • patients who are scheduled to undergo a major spine surgery in the prone position
• Exclusion Criteria:
• • patients who refuse to participate
• • body mass index: \<15kg/m2 or \>35kg/m2
• • patients with uncontrolled hypertension, hyperthyroidism, severe cardiac disease
• • patients who are contraindicated to the use of remimazolam including severe hepatic disease, acute glaucoma, shock, acute alcohol intoxication
• • allergic to propofol and midazolam
• • patients who are judged unsuitable to participate in the study for other reasons by medical staffs