Optimizing Door-to-reperfusion Times of One-stop Management in Acute Ischemic Stroke

Launched by CAN THO STROKE INTERNATIONAL SERVICES HOSPITAL · Dec 8, 2022

Keywords

ClinConnect Summary

Acute ischemic stroke is one of the diseases associated with stroke onset time, especially in the case of large vessel occlusion within 6 hours. This is the reason why endovascular reperfusion therapy (mechanical thrombectomy, angioplasty, stent,...) is recommended to be performed as soon as possible in the comprehensive stroke centers. The successful recanalization within 6 hours demonstrated the efficacy that helps to improve the functional outcome by trials. Besides, the strategies shortening time from admission to successful recanalization are essential for the treatment of acute ischem...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute ischemic stroke in the anterior circulation caused by large vessel occlusion.
• • National Institute of Health Stroke Scale (NIHSS) ≥10.
• • Premorbid modified Rankin Scale (mRS) ≤ 2
• • Target Mismatch profile: CBF \< 30% volume \< 100ml, Mismatch volume ≥ 15 ml and Mismatch Ratio \>1.8.
• • Available angiosuite.
• • CBF \< 30% volume: 70 - 100 ml when non-contrast computed tomography (NCCT) Alberta Stroke Program Early Computed Tomography Scores (ASPECTS) was 3 - 5 and/or beyond 6 hours after symptom onset
• Exclusion Criteria:
• • Evidence of intracranial tumors, the encephalitis, the hemorrhage: either an intracranial hemorrhage (ICH) or subarachnoid hemorrhage (SAH) by the biplane flat panel detector computed tomography.
• • Participated in another studies.
• • Loss to follow-up after discharge.
• • A severe or fatal combined illness before acute stroke.

Trial Officials