Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

Launched by CWM TAF UNIVERSITY HEALTH BOARD (NHS) · Dec 8, 2022

Keywords

ClinConnect Summary

The PREDICT-EV study is looking at how certain markers in the blood, called extracellular vesicles, can help predict the risk of stroke in patients who have experienced a Transient Ischemic Attack (TIA). TIAs are often warning signs that a stroke might happen, but currently, we don't have reliable ways to identify which TIA patients are at the highest risk. By studying 300 patients over a year, researchers hope to find out if these blood markers can help doctors better understand who needs more urgent care to prevent a stroke.

To participate in this trial, patients need to be over 18 years old and have either been diagnosed with a TIA or have had a stroke confirmed by medical imaging. Participants will be monitored and may need to provide blood samples during the study. It’s important to note that the study is currently recruiting patients and seeks to include individuals who are generally healthy enough to eat by mouth and can give consent for their participation. If you or someone you know fits these criteria, this study could be an important step toward better stroke prevention.

Gender

ALL

Eligibility criteria

• The inclusion criteria for phase 1 (initial patient recruitment) will be:
• • 1. Patients with or without diagnosis of TIA made by a physician working in stroke medicine, sufficiently so to start post-TIA care or so that no further investigation is thought necessary to confirm or refute the diagnosis.
• • 2. TIA confirmed patient has been prescribed antiplatelet drugs or anticoagulants.
• • 3. Patients must be aged \> 18 years.
• • 4. Patients are taking an ordinary diet by mouth.
• The inclusion criteria for phase 2 (patient representing with stroke) will be:
• • 1. Radiological evidence, on CT and/or MR imaging of the brain of cerebral infarction, with or without secondary haemorrhage.
• • 2. The underlying mechanism of cerebral infarction is embolic from a cardiac source (e.g. atrial fibrillation), atherothromboembolic (from aorta or other large vessels in the neck) or in-situ thrombosis. No further investigations are thought necessary to confirm or refute the diagnosis.
• • 3. No further investigations are thought necessary to confirm or refute the diagnosis.
• • 4. Patients must be aged \>18 years.
• • 5. Patients must not be pregnant or breast feeding.
• • 6. Patients are taking an ordinary diet by mouth. Exclusion Criteria
• The Exclusion criteria for phase 1 (initial patient recruitment) will be:
• • 1. Inability to give consent.
• • 2. Inability to feed by mouth.
• • 3. Short life expectancy.
• • 4. Pregnancy or breastfeeding.
• • 5. Symptoms are readily explained by medical problems not involving focal cerebral ischaemia.
• The Exclusion criteria for phase 2 (patient representing with stroke) will be:
• • 1. Patients who have not previously given consent for follow up blood sampling.
• • 2. Patients who are unable to feed by mouth.
• • 3. Patients in whom life expectancy is short.
• • 4. Patient is pregnant or breast feeding.