MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE

Launched by AUCKLAND CITY HOSPITAL · Nov 30, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how to manage blood pressure during a specific treatment for stroke called clot retrieval. Stroke is a serious condition that can lead to death or long-term disability, and this trial aims to find out if adjusting blood pressure during the procedure can improve outcomes for patients. The study is open to men and women aged 65 to 74 who have had a certain type of stroke and are treated within a specific timeframe.

If someone qualifies to participate, they can expect to receive the standard treatment for stroke while the researchers monitor their blood pressure closely. Participants will be required to have follow-up appointments for three months after the procedure to assess their recovery. It's important to know that some individuals may not be eligible due to other health conditions or if they are unable to complete the follow-up. This trial is a significant step in understanding how to enhance the care of stroke patients during these critical procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients diagnosed with anterior circulation stroke (ICA or proximal M1 or M2 segment of MCA) treated with ECR within 6 hrs of stroke onset and ECR patients presenting within 6-24 hours and favourable penumbra on perfusion scanning (see criteria 1-3).
• • Additional criteria in the 6 to 24-hour window.
• • 1. 'wake up' stroke; CT with no (or at most minimal) acute infarction or
• • 2. patient 80 years or older (NIHSS of 10 and infarct volume less than 21 ml on DWI or CT perfusion-CBF)
• • 3. patient less than 80 years (NIHSS of 10 and infarct volume less than 31 ml on DWI or CT perfusion-CBF NIHSS of 20 and infarct volume less than 51 ml on DWI or CT perfusion-CBF).
• Exclusion Criteria:
• • Rescue"' procedures eg acute ischaemic stroke associated with major medical procedures such as coronary artery stenting and coronary artery bypass
• • pre-stroke mRS\>=3
• • not having GA
• • terminal illness with expected survival \<1 year
• • pregnancy
• • cardiovascular conditions where BP targeting will be contra-indicated
• • unable to participate in 3-month follow up

Trial Officials