Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)
Launched by UNIVERSITY OF HULL · Dec 1, 2022
Trial Information
Current as of January 14, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Background:
Polycystic ovary syndrome (PCOS) is one of the most common metabolic disorders that affects 6-20% of reproductive-aged women and has an increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. Obesity affects more than 50% of women with PCOS and has been demonstrated to play a vital role in the establishment of symptoms in these patients. Bariatric surgery has been shown to improve metabolic parameters but reports of dietary intervention studies have been variable. PCOS is associated with an increased risk of depressive symptoms and a low quality of life (...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • 1. Willingness and ability to provide signed informed consent prior to any trial activity.
- • 2. Women, aged 18-45 years (inclusive), with confirmed diagnosis of PCOS based on Rotterdam criteria \[12\].
- • 3. Body mass index ≥30 kg/m2
- • 4. Negative pregnancy test during screening visit and agree to use barrier contraception during the study period.
- • 5. Participants from all ethnicities who are English speakers
- Exclusion Criteria:
- • 1. Non-classical 21-hydroxylase deficiency, hyperprolactinaemia, Cushing's disease, and androgen-secreting tumours will be excluded by appropriate tests.
- • 2. Confirmed type 2 diabetes and type 1 diabetes.
- • 3. Pregnancy, breastfeeding or intends to become pregnant.
- 4. Subjects who are on any of the following medications within 3 months of screening:
- • Metformin or other insulin-sensitizing medications (e.g. pioglitazone)
- • Hormonal contraceptives (e.g. birth control pills, hormone-releasing implants. Locally acting hormone - containing IUD such as Mirena coil is permitted).
- • Anti-androgens (e.g., spironolactone, flutamide, finasteride, etc.)
- • Clomiphene citrate or oestrogen modulators such as letrozole
- • GnRH modulators such as leuprolide
- • Minoxidil
- • 5. Have been involved in another medicinal trial (CTIMP) within the past four weeks.
- • 6. Presence or history of neoplasm within 5 years prior to screening. Basal skin carcinoma is allowed.
- • 7. History of pancreatitis
- • 8. Any regular medications that would affect weight management (such as steroids)
- • 9. Any contraindications for treatment with semaglutide.
- • 10. Participants under 18 years
- • 11. Participants who cannot adequately understand verbal and / or written explanations given in English.
- • 12. Confirmed excessive and compulsive drinking of alcohol i.e., alcohol abuse as determined from GP medical notes by the Fast Alcohol Screening Test (FAST) or history of previous alcohol abuse.
- • 13. Moderate to severe renal impairment (creatinine clearance \[CrCl\] ≤ 60 ml/min or estimated glomerular filtration rate \[eGFR\] ≤ 60 ml/min/1.73 m2.
- • 14. Severe hepatic insufficiency / and or significant abnormal liver function defines as aspartate aminotransferase (AST) \>3x upper limit of normal (ULN) and / or alanine aminotransferase (ALT) \> 3ULN.
- • 15. History of a major surgical procedure involving the stomach or small intestine which could affect absorption as judged by the investigator.
- • 16. Have severe and enduring mental health problems.
- • 17. Personal or first-degree relative history of multiple endocrine neoplasia type 2 (MEN2) or medullary thyroid cancer (MTC).
- • 18. Clinical or radiological evidence of thyroid nodules.
- • 19. Any contraindication to the administration of metformin.
Trial Officials
Thozhukat Sathyapalan, MD, FRCP
Principal Investigator
University of Hull
About University Of Hull
The University of Hull is a leading academic institution in the UK, renowned for its commitment to advancing research and innovation in various fields, including healthcare and clinical sciences. With a strong emphasis on interdisciplinary collaboration, the university fosters an environment that promotes cutting-edge clinical trials aimed at improving patient outcomes and advancing medical knowledge. Its research initiatives are supported by a diverse team of experts and state-of-the-art facilities, positioning the University of Hull as a key contributor to the development of effective treatments and healthcare solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hull, , United Kingdom
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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