A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP)
Launched by NOVO NORDISK A/S · Dec 2, 2022
Trial Information
Current as of May 31, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Male or female.
- • Age above or equal to 18 years at the time of signing informed consent.
- • Body mass index (BMI) greater than or equal to 30.0 kilogram per square meter (kg/m\^2).
- • History of at least one self-reported unsuccessful dietary effort to lose body weight.
- Exclusion Criteria:
- • HbA1c greater than or equal to 48 millimoles per mole (mmol/mol) (6.5 percent) as measured by the central laboratory at screening.
- • History of type 1 or type 2 diabetes.
- • Treatment with glucose-lowering agent(s) within 90 days before screening.
- • A self-reported change in body weight greater than 5 kilograms (kg) (11 pounds) within 90 days before screening irrespective of medical records.
- • Personal or first-degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma.
About Novo Nordisk A/S
Novo Nordisk A/S is a global healthcare company headquartered in Denmark, specializing in the research, development, manufacturing, and marketing of innovative pharmaceuticals, particularly in the fields of diabetes care, obesity treatment, and hormone replacement therapies. With a strong commitment to improving patient outcomes, Novo Nordisk invests significantly in clinical trials to advance scientific knowledge and develop effective therapies. The company is dedicated to sustainability and ethical practices, striving to deliver high-quality healthcare solutions while addressing the evolving needs of patients worldwide. Through collaboration and innovation, Novo Nordisk aims to lead the way in transforming diabetes and other chronic diseases into manageable conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Charleston, South Carolina, United States
Walnut Creek, California, United States
Chapel Hill, North Carolina, United States
Birmingham, Alabama, United States
Charleston, South Carolina, United States
Jacksonville, Florida, United States
Rehlingen Siersburg, , Germany
Montgomery, Alabama, United States
Greensboro, North Carolina, United States
Dallas, Texas, United States
Richmond, Virginia, United States
Halifax, Nova Scotia, Canada
Indianapolis, Indiana, United States
Birmingham, Alabama, United States
Presov, , Slovakia
Katowice, , Poland
Porto, , Portugal
Walnut Creek, California, United States
Tønsberg, , Norway
Athens, , Greece
Hamar, , Norway
Honolulu, Hawaii, United States
Wangen, , Germany
Bloemfontein, Free State, South Africa
Falkensee, , Germany
Johannesburg, Gauteng, South Africa
Sugar Land, Texas, United States
Hamilton, Ontario, Canada
Lucenec, , Slovakia
Amarillo, Texas, United States
Longview, Texas, United States
Elsterwerda, , Germany
Umkomaas, Kwazulu Natal, South Africa
London, Ontario, Canada
Lukovit, , Bulgaria
Budapest, , Hungary
Lisboa, , Portugal
Matosinhos, , Portugal
Székesfehérvár, , Hungary
Winchester, Virginia, United States
Berlin, , Germany
London, Ontario, Canada
Essen, , Germany
Budapest, , Hungary
Petrich, , Bulgaria
Smolyan, , Bulgaria
Baja, , Hungary
Praha 10, , Czechia
Halifax, Nova Scotia, Canada
Kozloduy, , Bulgaria
Essen, , Germany
Sofia, , Bulgaria
Port Elizabeth, Eastern Cape, South Africa
Albany, New York, United States
Oldenburg I. Holst, , Germany
Porto, , Portugal
Surrey, British Columbia, Canada
Chapel Hill, North Carolina, United States
Oslo, , Norway
Broumov, , Czechia
Orlando, Florida, United States
Warszawa, , Poland
Vila Nova De Gaia, , Portugal
Haidari Athens, , Greece
Praha 4, , Czechia
Witten, , Germany
Lamia, , Greece
Port Elizabeth, Eastern Cape, South Africa
Malacky, , Slovakia
Zilina, , Slovakia
Münster, , Germany
Debrecen, , Hungary
Nyíregyháza, , Hungary
Surrey, British Columbia, Canada
Orlando, Florida, United States
Tønsberg, , Norway
Thessaloniki, , Greece
Praha, , Czechia
Debrecen, , Hungary
Lublin, Lubelskie, Poland
Warsaw, Mazowieckie, Poland
Gdynia, Pomorskie, Poland
Warszawa, Mazowieckie, Poland
Krakow, Malopolskie, Poland
Bialystok, Podlaskie, Poland
Austin, Texas, United States
Martin, , Slovakia
Chapel Hill, North Carolina, United States
Varna, , Bulgaria
Benátky Na Jizerou, , Czechia
Bratislava, , Slovakia
Durban, Kwazulu Natal, South Africa
Warsaw, Mazowieckie, Poland
Warszawa, Mazowieckie, Poland
Baja, Bács Kiskun, Hungary
Austin, Texas, United States
Oldenburg In Holstein, , Germany
Jacksonville, Florida, United States
Honolulu, Hawaii, United States
Greensboro, North Carolina, United States
Amarillo, Texas, United States
Longview, Texas, United States
Richmond, Virginia, United States
Winchester, Virginia, United States
Hamilton, Ontario, Canada
Elsterwerda, , Germany
Wangen, , Germany
Kozloduy, , Bulgaria
Sofia, , Bulgaria
Hamilton, Ontario, Canada
Oldenburg In Holstein, , Germany
Witten, , Germany
Krakow, Malopolskie, Poland
Bialystok, Podlaskie, Poland
Gdynia, Pomorskie, Poland
Katowice, , Poland
Johannesburg, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Durban, Kwazulu Natal, South Africa
Sugar Land, Texas, United States
Athens, , Greece
Athens, , Greece
Haidari Athens, , Greece
Thessaloniki, , Greece
Thessaloniki, , Greece
Budapest, , Hungary
Budapest, , Hungary
Lamia, , Greece
Lublin, Lubelski, Poland
Matosinhos, , Portugal
Johannesburg, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Broumov, , Czechia
Warszawa, , Poland
Sofia, , Bulgaria
Berlin, , Germany
Thessaloniki, , Greece
Athens, , Greece
Thessaloniki, , Greece
Montgomery, Alabama, United States
Praha 4, , Czechia
Hamar, , Norway
Lublin, Lubelskie, Poland
Essen, , Germany
Lucenec, , Slovakia
Falkensee, , Germany
Lisboa, , Portugal
Thessaloniki, , Greece
Dallas, Texas, United States
Münster, , Germany
Rehlingen Siersburg, , Germany
Halifax, Nova Scotia, Canada
Thessaloniki, , Greece
Umkomaas, Kwazulu Natal, South Africa
Debrecen, Hajdu Bihar Varmegye, Hungary
Nyíregyháza, Szabolcs Szatmar Varmegye, Hungary
Austin, Texas, United States
Warszawa, , Poland
Bloemfontein, Free State, South Africa
Petrich, , Bulgaria
Indianapolis, Indiana, United States
Dallas, Texas, United States
Baja, Bács Kiskun Vármegye, Hungary
Praha, , Czechia
Orlando, Florida, United States
Lukovit, , Bulgaria
Smolyan, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Varna, , Bulgaria
Benátky Na Jizerou, , Czechia
Praha 10, , Czechia
Praha 4, , Czechia
Praha 4, , Czechia
Székesfehérvár, , Hungary
Oslo, , Norway
Bratislava, , Slovakia
Bratislava, , Slovakia
Malacky, , Slovakia
Martin, , Slovakia
Presov, , Slovakia
Zilina, , Slovakia
Zilina, , Slovakia
Durban, Kwazulu Natal, South Africa
Lucenec, , Slovakia
Haidari Athens, Attica, Greece
Senhora Da Hora, Matosinhos, Portugal
Münster, , Germany
Hamilton, Ontario, Canada
Athens, Attica, Greece
Athens, , Greece
Senhora Da Hora, Matosinhos, Matosinhos, Portugal
Athens, , Greece
Porto, , Portugal
Thessaloniki, , Greece
Thessaloniki, , Greece
Senhora Da Hora, Matosinhos, Matosinhos, Portugal
Athens, , Greece
Lamia, , Greece
Patients applied
Trial Officials
Clinical Transparency (dept. 2834)
Study Director
Novo Nordisk A/S
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials