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Search / Trial NCT05647200

Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II

Launched by AMSTERDAM UMC, LOCATION VUMC · Dec 9, 2022

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Trial Information

Current as of February 05, 2025

Not yet recruiting

Keywords

Microcirculation Cardiopulmonary Bypass Colloid Oncotic Pressure Hemodilution Hemolysis

ClinConnect Summary

In this project the investigators focus on reducing microcirculatory perfusion disturbances by exploring therapeutic approaches with different prime fluid strategies, by acting on COP (part I) and free hemoglobin scavenging with human albumin (part II).

In part I, patients undergoing elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass will be randomized in three groups receiving different prime fluid strategies. The study endpoint is the reduction in functional capillary density during the perioperative period. Sublingual microcirculatory measurements and blood...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Adult subjects
  • • Informed consent
  • • Elective coronary artery bypass surgery with cardiopulmonary bypass
  • Exclusion Criteria:
  • • Emergency operations
  • • Re-operation
  • • Elective thoracic aortic surgery
  • • Elective valve surgery
  • • Combined procedure CABG and valve surgery
  • • Known allergy for human albumin or gelofusine

Trial Officials

A.B.A. Vonk, MD, PhD

Principal Investigator

Cardiothoracic surgeon

About Amsterdam Umc, Location Vumc

Amsterdam UMC, located at VU Medical Center (VUmc), is a leading academic medical center in the Netherlands dedicated to advancing healthcare through innovative research and clinical trials. With a strong emphasis on translating scientific discoveries into practical applications, Amsterdam UMC collaborates closely with researchers, healthcare professionals, and industry partners to enhance patient outcomes. The institution is committed to rigorous ethical standards and regulatory compliance, ensuring the integrity and reliability of its clinical research initiatives across various medical disciplines.

Locations

Amsterdam, Noord Holland, Netherlands

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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