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The Efficacy of L-Carnitine in the Management of Acute Carbon Monoxide Poisoning

Launched by ALEXANDRIA UNIVERSITY · Dec 8, 2022

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Trial Information

Current as of January 22, 2025

Unknown status

Keywords

Carbon Monoxide Poisoning Cardiotoxicity Troponin L Carnitine Outcome

ClinConnect Summary

A randomized clinical trial (phase II) will be conducted at Alexandria Main University Hospital.

The total required sample size is 72. The sample size was calculated by G power 3.1.9.4 software program depending on the primary outcome. According to these assumptions: Effect size, defined as the difference between group 1 and group 2 in the mean troponin levels at 24 hr, was calculated according to Sun et al. (2011) and was 0.657, alpha error =0.05, power of 80%, allocation ratio 1:1. A 20% expected attrition was added to the sample size to account for loss to follow-up. So, the final sampl...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • The current clinical trials will include patients with moderate and severe acute carbon monoxide poisoning according to Poisoning Severity Score.
  • Exclusion Criteria:
  • • When the diagnosis of acute carbon monoxide poisoning is unconfirmed.
  • • Patients with advanced cardiac and neurological diseases.

Trial Officials

Zahraa K Sobh, MD

Principal Investigator

Associate Professor of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Maha A Ghanem, MD

Principal Investigator

Professor of Forensic Medicine and Clinical Toxicology. Head of department of Forensic Medicine and Clinical Toxicology. Chairperson of ethics committee Faculty of Medicine

Heidi A Elsobky, MS

Study Director

Assistant Lecturer of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Farah S Habib, Bachelor

Study Director

Demonstrator of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Fatma Elgazzar, MD

Principal Investigator

Professor of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Alexandria, Egypt

About Alexandria University

Alexandria University, a leading academic institution in Egypt, is dedicated to advancing medical research and improving healthcare outcomes through innovative clinical trials. With a strong emphasis on collaboration and interdisciplinary approaches, the university leverages its extensive resources and expertise to conduct rigorous studies that address pressing health challenges. By fostering partnerships with healthcare professionals, industry leaders, and regulatory bodies, Alexandria University aims to contribute to the global body of medical knowledge and enhance the quality of patient care through evidence-based findings.

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Timeline

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Trial launched

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Estimated completion

Not reported

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