CSF Biomarkers in Idiopathic Intracranial Hypertension

Launched by ASSIUT UNIVERSITY · Nov 30, 2022

Keywords

ClinConnect Summary

Idiopathic intracranial hypertension (IIH) is a rare disease of increasing incidence recently\[1\], owing to the rising curve of obesity and weight gain\[2,3\]. It is a disease of elevated intracranial pressure without known obvious aetiology. The reported incidence of IIH is 1 to 3 cases per 100,000 people of the general population\[4\]. IIH is diagnosed by exclusion; as patients come with continuous headache repeated vomiting , pulsatile tinnitus and the hall landmark of this disease, visual disturbance. One of the most deleterious effect of IIH is through its effect on optic nerve (papil...

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Eligibility criteria

• Inclusion Criteria:
• • - 1. All patients with signs and symptoms of increased intracranial pressure (headaches, nausea, vomiting, transient visual obscurations, papilledema).
• • 2. CSF opening pressure \>25 cm water with normal CSF composition.
• Exclusion Criteria:
• • 1. localizing neurologic signs, except for unilateral or bilateral sixth cranial nerve palsy.
• • 2. Evidence of hydrocephalus, mass, infection, structural, or vascular lesion (including venous sinus thrombosis) on imaging.
• • 3. Patients with IIH who undergo surgical intervention (thecoperitoneal shunt or optic nerve fenestration) 4. Other identified causes of increased ICP.

Trial Officials