Trials
Search / Trial NCT05647837

CSF Biomarkers in Idiopathic Intracranial Hypertension

Launched by ASSIUT UNIVERSITY · Nov 30, 2022

Trial Information

Current as of January 16, 2025

Unknown status

Keywords

Biomarkers

ClinConnect Summary

Idiopathic intracranial hypertension (IIH) is a rare disease of increasing incidence recently\[1\], owing to the rising curve of obesity and weight gain\[2,3\]. It is a disease of elevated intracranial pressure without known obvious aetiology. The reported incidence of IIH is 1 to 3 cases per 100,000 people of the general population\[4\]. IIH is diagnosed by exclusion; as patients come with continuous headache repeated vomiting , pulsatile tinnitus and the hall landmark of this disease, visual disturbance. One of the most deleterious effect of IIH is through its effect on optic nerve (papil...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • - 1. All patients with signs and symptoms of increased intracranial pressure (headaches, nausea, vomiting, transient visual obscurations, papilledema).
  • 2. CSF opening pressure \>25 cm water with normal CSF composition.
  • Exclusion Criteria:
  • 1. localizing neurologic signs, except for unilateral or bilateral sixth cranial nerve palsy.
  • 2. Evidence of hydrocephalus, mass, infection, structural, or vascular lesion (including venous sinus thrombosis) on imaging.
  • 3. Patients with IIH who undergo surgical intervention (thecoperitoneal shunt or optic nerve fenestration) 4. Other identified causes of increased ICP.

Trial Officials

Mahmoud H Ragab, professor

Study Chair

professor

Abdelhakeem A Essa, Ass. prof.

Study Director

Assistant professor

About Assiut University

Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.

Locations

Assiut, , Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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