Trials
Search / Trial NCT05648526

Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10

Launched by UNIVERSITAS SUMATERA UTARA · Dec 5, 2022

Apply for Trial

Trial Information

Current as of February 05, 2025

Completed

Keywords

Acth4 10 Pro8 Gly9 Pro10 Bdnf Ketamine Induced Neurotoxicity Apoptosis

ClinConnect Summary

The compound ACTH4-10Pro8-Gly9-Pro10 is a synthetic analog molecule of a short fragment of adrenocorticotropic hormone (ACTH). It is free from hormonal effects and has neuromodulatory effects. The immune-modulating and neurotrophic activity of the drug were shown to balance the state of anti-inflammatory and trophic factors (IL-IO, TNF-a, TGF-Pl, BDNF, NGF) over proinflammatory factors (IL-Ip, IL-8, CRP, LE) to increase the anti-apoptotic defense (Bcl-2 elevation), as well as to reduce the peroxidation process (increased SOD activity).

ACTH4-10Pro8-Gly9-Pro10 also has neuromodulator charac...

Gender

MALE

Eligibility criteria

  • Inclusion Criteria:
  • • Rattus norvegicus rats
  • • Male, seven days old, weighing 15-20 grams
  • • Spraque-Dawley strain, obtained from the Experimental Animal Care Unit
  • Exclusion Criteria:
  • • Animals that behave aggressively in observation by attacking other groups

About Universitas Sumatera Utara

Universitas Sumatera Utara (USU) is a leading academic institution based in Medan, Indonesia, dedicated to advancing medical research and clinical trials. With a commitment to fostering innovation in healthcare, USU collaborates with various stakeholders to conduct rigorous studies aimed at improving patient outcomes and informing clinical practices. The university's research initiatives are supported by a team of experienced professionals and state-of-the-art facilities, ensuring adherence to ethical standards and regulatory requirements. As a prominent sponsor of clinical trials, USU plays a vital role in contributing to the global body of medical knowledge and enhancing the quality of care within the region.

Locations

Medan, Sumatera Utara, Indonesia

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

Similar Trials