Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke

Launched by THE AFFILIATED NANJING DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL · Dec 5, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how certain connections in the brain change after a stroke and how these changes relate to a person's ability to move. The researchers are using special brain imaging techniques called MRI to look at these connections in people who have had a stroke that affects one side of the brain and have difficulty with movement. The goal is to better understand how these brain patterns can influence motor function, which is important for recovery.

To be part of this study, participants should be between 30 and 75 years old, right-handed before their stroke, and at least three months past their first stroke. They should have stable health and be able to understand and sign the consent form. However, those with serious health issues, other brain diseases, or difficulties with communication may not be eligible. If you join the study, you'll have an MRI scan to help researchers learn more about how to improve movement after a stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Comply with the diagnostic criteria of "Stroke" in the 2010 "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China," and confirmed by head CT or MRI.
• • 2. First onset unilateral subcortical stroke (basal ganglia, thalamus, internal capsule, corona radiata, lateral ventricles, etc.).
• • 3. Age ranged from 30 to 75 years old.
• • 4. Right-handedness before stroke.
• • 5. Greater than three months since stroke onset and Brunnstrom graded as III-VI; 6. The condition and vital signs are stable.
• • 7. Sign the informed consent form.
• Exclusion Criteria:
• • 1. Any contraindications for the MRI examination.
• • 2. History of other brain diseases and drug dependency.
• • 3. Unstable conditions or accompanied by malignant and rapidly progressing diseases, such as severe atrial fibrillation.
• • 4. Serious communication barriers, cognitive impairment, or cooperation with difficulties.