A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight
Launched by NOVO NORDISK A/S · Dec 5, 2022
Trial Information
Current as of January 13, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Male or female.
- • Age above or equal to 18 years at the time of signing informed consent.
- • BMI greater than or equal to 30.0 kilograms per square meter (kg/m\^2).
- • Diagnosed with type 2 diabetes (T2D) greater than or equal to 180 days prior to the day of screening.
- • History of at least one self-reported unsuccessful dietary effort to lose body weight.
- • HbA1c 7.0-10.0 percent (53-86 millimoles per mole \[mmol/mol\]) (both inclusive) as measured by central laboratory at screening.
- Exclusion Criteria:
- • A self-reported change in body weight greater than 5 kilograms (kg) (11 pounds \[lbs\]) within 90 days before screening irrespective of medical records.
- • Personal or first-degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma.
- • Renal impairment with estimated Glomerular Filtration Rate (eGFR) less than 30 milliliters per minute per 1.73 square meter (30 mL/min/1.73 m\^2) (less than 45 mL/min/1.73 m\^2 in participants treated with Sodium-glucose Cotransporter-2 \[SGLT2i\]) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation as defined by Kidney Disease: Improving Global Outcomes (KDIGO) 2012 by the central laboratory at screening.
- • Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
Trial Officials
Clinical Transparency (dept. 2834)
Study Director
Novo Nordisk A/S
About Novo Nordisk A/S
Novo Nordisk A/S is a global healthcare company headquartered in Denmark, specializing in the research, development, manufacturing, and marketing of innovative pharmaceuticals, particularly in the fields of diabetes care, obesity treatment, and hormone replacement therapies. With a strong commitment to improving patient outcomes, Novo Nordisk invests significantly in clinical trials to advance scientific knowledge and develop effective therapies. The company is dedicated to sustainability and ethical practices, striving to deliver high-quality healthcare solutions while addressing the evolving needs of patients worldwide. Through collaboration and innovation, Novo Nordisk aims to lead the way in transforming diabetes and other chronic diseases into manageable conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Walnut Creek, California, United States
Chapel Hill, North Carolina, United States
Birmingham, Alabama, United States
Jacksonville, Florida, United States
Montgomery, Alabama, United States
Los Angeles, California, United States
Greensboro, North Carolina, United States
Dallas, Texas, United States
Concord, California, United States
Richmond, Virginia, United States
Halifax, Nova Scotia, Canada
Birmingham, Alabama, United States
Presov, , Slovakia
Katowice, , Poland
Porto, , Portugal
Walnut Creek, California, United States
Bloemfontein, Free State, South Africa
Johannesburg, Gauteng, South Africa
Sofia, , Bulgaria
Sugar Land, Texas, United States
Golden, Colorado, United States
Hamilton, Ontario, Canada
Deland, Florida, United States
Stara Zagora, , Bulgaria
Amarillo, Texas, United States
Burgas, , Bulgaria
Longview, Texas, United States
Umkomaas, Kwazulu Natal, South Africa
London, Ontario, Canada
Presov, , Slovakia
Budapest, , Hungary
Lisboa, , Portugal
Matosinhos, , Portugal
Székesfehérvár, , Hungary
Winchester, Virginia, United States
Houston, Texas, United States
London, Ontario, Canada
Budapest, , Hungary
Moncton, New Brunswick, Canada
Sliven, , Bulgaria
Bardejov, , Slovakia
Povazska Bystrica, , Slovakia
Oviedo, Florida, United States
Baja, , Hungary
Moncton, New Brunswick, Canada
Blagoevgrad, , Bulgaria
Sofia, , Bulgaria
Port Elizabeth, Eastern Cape, South Africa
Albany, New York, United States
Porto, , Portugal
Oviedo, Florida, United States
Surrey, British Columbia, Canada
Chapel Hill, North Carolina, United States
Birmingham, Alabama, United States
Orlando, Florida, United States
Warszawa, , Poland
Vila Nova De Gaia, , Portugal
Pazardzhik, , Bulgaria
Port Elizabeth, Eastern Cape, South Africa
Bytca, , Slovakia
Concord, California, United States
Debrecen, , Hungary
Nyíregyháza, , Hungary
Surrey, British Columbia, Canada
Yambol, , Bulgaria
Conyers, Georgia, United States
Debrecen, , Hungary
Lublin, Lubelskie, Poland
Warsaw, Mazowieckie, Poland
Concord, California, United States
Gdynia, Pomorskie, Poland
Warszawa, Mazowieckie, Poland
Krakow, Malopolskie, Poland
Plovdiv, , Bulgaria
Bialystok, Podlaskie, Poland
Austin, Texas, United States
Chapel Hill, North Carolina, United States
Durban, Kwazulu Natal, South Africa
Dobrich, , Bulgaria
Kosice, , Slovakia
Warsaw, Mazowieckie, Poland
Warszawa, Mazowieckie, Poland
Baja, Bács Kiskun, Hungary
Austin, Texas, United States
Johannesburg, Gauteng, South Africa
Warszawa, , Poland
Jacksonville, Florida, United States
Greensboro, North Carolina, United States
Amarillo, Texas, United States
Houston, Texas, United States
Longview, Texas, United States
Richmond, Virginia, United States
Winchester, Virginia, United States
Hamilton, Ontario, Canada
Plovdiv, , Bulgaria
Stara Zagora, , Bulgaria
Yambol, , Bulgaria
Hamilton, Ontario, Canada
Krakow, Malopolskie, Poland
Bialystok, Podlaskie, Poland
Katowice, , Poland
Johannesburg, Gauteng, South Africa
Durban, Kwazulu Natal, South Africa
Sugar Land, Texas, United States
Budapest, , Hungary
Budapest, , Hungary
Lublin, Lubelski, Poland
Matosinhos, , Portugal
Johannesburg, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Warszawa, , Poland
Conyers, Georgia, United States
Bardejov, , Slovakia
Lublin, Lubelskie, Poland
Sliven, , Bulgaria
Lisboa, , Portugal
Dallas, Texas, United States
Sofia, , Bulgaria
Halifax, Nova Scotia, Canada
Umkomaas, Kwazulu Natal, South Africa
Debrecen, Hajdu Bihar Varmegye, Hungary
Nyíregyháza, Szabolcs Szatmar Varmegye, Hungary
Austin, Texas, United States
Warszawa, , Poland
Bloemfontein, Free State, South Africa
Baja, Bács Kiskun Vármegye, Hungary
Orlando, Florida, United States
Székesfehérvár, , Hungary
Durban, Kwazulu Natal, South Africa
Dallas, Texas, United States
Los Angeles, California, United States
Golden, Colorado, United States
Deland, Florida, United States
Blagoevgrad, , Bulgaria
Burgas, , Bulgaria
Dobrich, , Bulgaria
Pazardzhik, , Bulgaria
Bytca, , Slovakia
Kosice, , Slovakia
Povazska Bystrica, , Slovakia
Concord, California, United States
Concord, California, United States
Bardejov, , Slovakia
Senhora Da Hora, Matosinhos, Portugal
Stara Zagora, , Bulgaria
Hamilton, Ontario, Canada
Hamilton, Ontario, Canada
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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