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Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Dec 5, 2022

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Trial Information

Current as of January 17, 2025

Recruiting

Keywords

Esc 0/1 Hour Algorithm Emergency Department Chest Pain Chest Discomfort Myocardial Infarction Mi Acute Myocardial Infarction Ami Acute Coronary Syndrome Acs Nstemi Non St Segment Elevation Myocardial Infarction Nste Acs Non St Segment Elevation Acute Coronary Syndrome Unstable Angina Damaged Muscle Of The Heart Cardiac Biomarkers Cardiac Troponin T C Tn T Cardiac Specific Troponin T Cardiac Troponin I C Tn I Cardiac Specific Troponin I Amount Of Troponin In The Bloodstream Increased Troponin Level Elevated Troponin Level High Troponin Level Troponin Assessment Measurement Of Troponin Levels High Sensitive Troponin Test High Sensitivity Troponin T Testing High Sensitive Troponin T Hs Tn T C Tn T Hs High Sensitive Troponin I Hs Tn I C Tn I Hs High Sensitivity Cardiac Troponin Assays Ed Presentation Ed Admission Ed Work Up Triage Emergency Department Triage Emergency Room Triage Emergency Hospital Rapid Rule Out Of Acute Myocardial Infarction Shorter Stay In The Emergency Department Esc 0/3 Hour Algorithm Esc Guidelines European Guidelines 0/1 Hour Algorithm 0/3 Hour Algorithm

ClinConnect Summary

The PRESC1SE-MI study is looking at how to quickly and accurately evaluate patients who arrive at the emergency department with chest pain that might be a heart attack. It compares two methods for testing levels of a heart protein called troponin, which helps doctors understand if there has been damage to the heart. The first method tests troponin levels at the time of admission and again after three hours, while the newer method tests at admission and again after just one hour. This study will help determine if the faster method is just as safe and effective as the traditional one.

To participate in this trial, you need to be at least 18 years old and experiencing chest pain that isn’t the result of an injury, with a suspicion of a heart attack. However, people with severe kidney problems, who have had a cardiac arrest, or who are in a serious condition called cardiogenic shock cannot take part. If eligible, participants will have their blood tested for troponin levels at the specified times, allowing researchers to see how well the quicker method works in real-life situations. This could eventually lead to faster diagnoses and treatment for heart attacks in the emergency department.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Patients aged 18 and above
  • • Presentation with acute non-traumatic acute chest pain to the emergency department
  • • Suspicion of acute myocardial infarction
  • Exclusion Criteria:
  • • Terminal kidney failure requiring dialysis
  • • Cardiac arrest
  • • Cardiogenic shock

Trial Officials

Christian Müller, MD Prof.

Principal Investigator

University Hospital, Basel, Switzerland

Jasper Boeddinghaus, MD

Principal Investigator

University Hospital, Basel, Switzerland

About University Hospital, Basel, Switzerland

The University Hospital Basel, Switzerland, is a leading academic medical center renowned for its commitment to cutting-edge research and innovative patient care. As a prominent clinical trial sponsor, the hospital leverages its extensive expertise and state-of-the-art facilities to advance medical knowledge and therapeutic options across various disciplines. With a collaborative approach that integrates clinical practice and scientific inquiry, the University Hospital Basel fosters an environment conducive to rigorous clinical trials, ensuring the highest standards of safety and efficacy. Its strategic focus on patient-centered research aims to translate scientific discoveries into tangible health solutions, benefiting both local and global communities.

Locations

Barcelona, , Spain

Leicester, , United Kingdom

Aarau, , Switzerland

Aarau, Aargau, Switzerland

London, , United Kingdom

Luzern, , Switzerland

Seoul, , Korea, Republic Of

Basel, , Switzerland

Valencia, , Spain

Houston, Texas, United States

Zürich, , Switzerland

Roma, , Italy

Madrid, , Spain

Brisbane, , Australia

Wien, , Austria

Helsinki, , Finland

Athens, , Greece

Florence, , Italy

Torino, , Italy

Bucharest, , Romania

Madrid, , Spain

Truro, , United Kingdom

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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