Transcranial Magnetic Stimulation in Smokers: an Examination of Mediating Neural Pathways.

Launched by KENT STATE UNIVERSITY · Dec 6, 2022

Keywords

ClinConnect Summary

The study will include functional magnetic resonance imaging at baseline as well as demographic, psychological, and tobacco use assessments. Following initial assessment, participants will undergo one active rTMS session (20 Hz rTMS, 900 pulses per session, applied to left DLPFC). The outcome session will include assessments repeated from baseline.

The current proposal will examine the following aims. Aim 1: To test the potential for active rTMS to improve cognitive control of craving. Hypothesis: Active rTMS (compared to sham rTMS) will result in significant improvement in control over cr...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Smokers endorsing atleast moderate dependence (total Fagerstrom for Cigarette Dependence score \> 4)
• • Endorsing no specific plan to quit smoking in the next 3 months.
• • Must meet safety guidelines for application of rTMS
• • 18-60 years of age
• • Smoked cigarettes regularly for at least one year
• • Currently smoke at least 10 cigarettes per day
• • Have a carbon monoxide (CO) level greater or equal to 10 ppm
• • Currently be using no other nicotine products.
• Exclusion Criteria:
• • Subjects will be excluded if they meet criteria for current alcohol (moderate - severe), current substance dependence, current affective disorder (depression, dysthymia, or mania) or current psychotic symptoms as assessed by the (MINI) International Neuropsychiatric Exam
• • Are currently pregnant or lactating, or intend to become pregnant
• • Have a health condition for which rTMS is contraindicated
• • Submit a urine drug screen positive for illicit substances or substance misuse.