SBRT Combined With Chemotherapy and Tislelizumab in Metastatic NPC

Launched by ZHEJIANG CANCER HOSPITAL · Dec 5, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring a new treatment approach for patients with advanced nasopharyngeal carcinoma (NPC), a type of cancer that can spread to other parts of the body. The study is looking at the effects of combining a specific type of radiation therapy called SBRT with two other treatments: chemotherapy and an immunotherapy drug called tislelizumab. The goal is to see if this combination can help control the cancer and improve survival rates for patients with metastatic NPC, meaning the cancer has spread beyond its original site.

To participate in this trial, patients must be between 18 to 75 years old, have a confirmed diagnosis of metastatic NPC, and have not received prior treatment for this condition. They should also have at least one area of cancer that can be treated with SBRT and a reasonable expectation of living for at least six months. Participants can expect to undergo regular treatments and check-ups to monitor their progress. It's important to note that there are specific health conditions that may exclude someone from joining the trial, so potential participants should discuss their medical history with their doctor to see if they qualify.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Signed a written informed consent form (ICF) voluntarily.
• • 2. Male or female, aged from 18 to 75 years.
• • 3. Pathologically confirmed newly diagnosed or treated metastatic patients are not suitable for radiotherapy.
• • 4. Have not received treatment for metastatic nasopharyngeal carcinoma.
• • 5. At least one metastatic lesion can be treated with SBRT.
• • 6. ECOG score 0-1.
• • 7. Expected survival expectancy of no less than 6 months.
• • 8. Adequate bone marrow/liver and kidney function/heart and lung and other physiological function reserves, expected to successfully complete chemoradiotherapy and immunotherapy.
• • 9. Women of childbearing potential must confirm a negative serum pregnancy test and agree to use effective contraception during study drug use and for 150 days after the last dose.
• • 10. Male patients with sexual partners of childbearing potential must agree to use effective contraception during study drug use and for 150 days after the last dose. Subject is willing and able to comply with visits, treatment regimen, laboratory tests, and other requirements of the study as specified in the schedule.
• • 11. Subjects are willing and able to comply with visits, treatment regimens, laboratory tests, and other requirements of the study as spe
• Exclusion Criteria:
• • 1. subjects with pathologically diagnosed adenocarcinoma or sarcoma of the nasopharynx.
• • 2. subject has other malignancy within 3 years prior to first dose except nasopharyngeal carcinoma. Subjects with other malignancies that have been cured by local therapy, such as basal or cutaneous squamous cell carcinoma, superficial bladder cancer, cervical or breast carcinoma in situ, are excluded.
• • 3. Participated in treatment with an investigational drug or used an investigational device within 4 weeks prior to the first dose.
• • 4. Active autoimmune disease requiring systemic treatment within 2 years prior to the first dose, or autoimmune disease that may recur or plan treatment as judged by the investigator.
• • 5. active or previous definite inflammatory bowel disease (e.g., Crohn 's disease or ulcerative colitis) disease.
• • 6. History of immunodeficiency; positive HIV antibody test; current chronic use of systemic corticosteroids or other immunosuppressive agents; local, ocular, intra-articular, intranasal, and inhaled corticosteroids are allowed.
• • 7. Subjects with known active pulmonary tuberculosis (TB) and suspected active TB require clinical examination to rule out; known active syphilis infection.
• • 8. known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation; 9. history of pneumonitis/interstitial lung disease requiring systemic corticosteroids or current pneumonitis.
• • 10. serious infections within 4 weeks prior to the first dose, including but not limited to comorbidities requiring hospitalization, sepsis, or serious pneumonia; active infections (excluding antiviral therapy for hepatitis B or C) that have received systemic anti-infective therapy within 2 weeks prior to the first dose.
• • 11. Subjects with untreated active hepatitis B (HBsAg positive and HBV-DNA more than 1000 copies/ml \[200 IU/ml\] or above the lower limit of detection) and anti-hepatitis B virus treatment during study treatment are required for subjects with hepatitis B; subjects with active hepatitis C (HCV antibody positive and HCV-RNA level above the lower limit of detection).
• • 12. any of the following cardiovascular and cerebrovascular diseases: a) myocardial infarction, unstable angina pectoris, cerebrovascular accident, transient ischemic attack, acute or persistent myocardial ischemia, symptomatic heart failure (Grade 2 and above according to the New York Heart Association functional classification), or any arterial thromboembolic event within 6 months before the first dose; b) history of venous thromboembolic events (NCI CTCAE 5.0 version 3 and above), pulmonary embolism, or other serious thromboembolism within 3 months before the first dose; c) presence of serious arrhythmia requiring long-term drug intervention; patients with asymptomatic atrial fibrillation with stable ventricular rate are allowed; d) presence of aortic aneurysm, aortic dissecting aneurysm, internal carotid artery stenosis and other major vascular diseases that may be life-threatening or require surgery within 6 months; e) previous history of myocarditis or cardiomyopathy.
• • 13. Known hypersensitivity to any component of any study drug; known history of serious hypersensitivity to other monoclonal antibodies.
• • 14. known history of mental illness, drug abuse, alcoholism, or drug abuse; 15. pregnant or lactating women. 16. Any previous or current illness, treatment, or laboratory abnormality that may confound the results of the study, affect the subject 's full participation in the study, or that participation may not be in the subject' s best interest.