A Study to Understand How the Study Medicine (PF-07081532) is Processed and Eliminated in Healthy Men

Launched by PFIZER · Dec 7, 2022

Keywords

ClinConnect Summary

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Gender

MALE

Eligibility criteria

• Key Eligibility criteria for this study include, but are not limited to the following:
• Inclusion criteria:
• • Healthy Male participants must be 18 to 60 years of age, inclusive.
• • Overtly healthy as determined by medical evaluation including medical history, physical examination, blood pressure and pulse rate measurement, standard 12-lead ECG, and laboratory tests.
• • BMI of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lb).
• • Participants who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures
• Exclusion criteria:
• • History of irregular bowel movements (eg, irritable bowel syndrome, frequent episodes of diarrhea, or constipation defined by less than 1 bowel movement on average per 2 days) or lactose intolerance
• • Any condition possibly affecting drug absorption (eg, gastrectomy, cholecystectomy).
• • Previous administration with an investigational product (drug or vaccine) within 90 days (or as determined by the local requirement) preceding the first dose of study intervention used in this study.
• • Total 14C radioactivity measured in plasma exceeding 11 mBq/mL.

Trial Officials