Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis

Launched by TIANJIN HUANHU HOSPITAL · Dec 15, 2022

Keywords

ClinConnect Summary

Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes of ischemic stroke, and its incidence varies widely among different ethnic groups. ICAS may represent approximately 10% of ischemic stroke in Caucasians and even be responsible for up to 50% in Chinese population. Recurrent stroke risks are as high as 23% 1 year after transient ischemic stroke (TIA) or stroke in patients with a stenosis of 70% or more. The Chinese IntraCranial AtheroSclerosis (CICAS) study indicated the prevalence of ICAS was 46.6%; Patients with ICAS had more severe stroke at admission and stayed lon...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient admitted from Jan. 1st 2023 to Jan. 1st 2025;
• • 2. Age ≥ 18;
• • 3. Intracranial atherosclerosis stenosis measured as ≥70% by digital subtraction angiography or by other noninvasive methods, such as transcranial doppler, computed tomography angiography, or magnetic resonance angiography;
• • 4. A history of stroke/transient ischemic attack attributed to ICAS;
• • 5. Verbal and written informed consent is provided at the time of admission by patients or their legally authorized representatives.
• Exclusion Criteria:
• • 1. Stenosis of other causes;
• • 2. Prior ipsilateral stroke with residual deficits;
• • 3. Uncontrolled hypertension (defined as systolic blood pressure ≥200 mm Hg despite medications at enrollment);
• • 4. Peripheral vascular disease (especially subclavian arterial and upper limb artery stenosis or occlusion).

Trial Officials