Effects of CSL324 in the Lung After Segmental Challenge

Launched by CSL BEHRING · Dec 15, 2022

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female volunteer.
• • Between the ages of ≥ 18 and ≤ 65 years.
• • Body mass index within the range of 18 to 32 kg/m2
• • Female of nonchildbearing potential or of childbearing potential and willing to use a highly effective method of contraception (in addition to male partner condom with or without spermicide)
• • Nonsmoker or an ex-smoker who has stopped smoking (including e-cigarettes or vaping devices) for \> 1 year with a smoking history of \< 10 pack-years.
• Exclusion Criteria:
• • Any clinically significant abnormalities in physical examination findings, electrocardiogram (ECG) readings, safety laboratory test results, or ANC \< 2.0 × 109 cells/L.
• • History of myeloproliferative or lymphoproliferative disease.
• • Current or previous history of any immunosuppressive condition.
• • Currently receiving any immunosuppressive or immunomodulatory therapy, or history of undergoing such therapy.

Trial Officials