Migraine in Adolescents

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Dec 6, 2022

Keywords

ClinConnect Summary

This clinical trial, titled "Migraine in Adolescents," is focused on understanding migraines in young people aged 10 to 13. The researchers aim to find out what factors might predict when a migraine will start, what changes happen in the body and brain during a migraine, and how these factors can help predict how well a young person with migraines will do in the future. The study is currently recruiting participants who either have migraines or are healthy but have a family history of migraines.

To be eligible for the trial, participants must be between 10 and 13 years old, and if they have migraines, they should have been experiencing them for more than six months. Healthy participants should not have any migraine symptoms and must have a first-degree relative (like a parent or sibling) diagnosed with migraines. Participants will undergo assessments to help researchers gather information, but they should not have other chronic pain conditions or disorders that could interfere with the study. This research could help improve understanding and treatment of migraines in adolescents, making it an important opportunity for those who qualify.

Gender

ALL

Eligibility criteria

• Inclusion criteria for healthy participants:
• • 1. Age 10-13
• • 2. Males or females (biological sex)
• • 3. Not diagnosed with migraine or having migraine symptoms
• • 4. With a first degree relative diagnosed with migraine (for the Fam-His group) or without a first or a second degree relative diagnosed with migraine (for the No-Fam-His group)
• Inclusion criteria for participants with migraine:
• • 1. Age 10-13
• • 2. Males or females (biological sex)
• • 3. Diagnosed with migraine or having migraine symptoms
• • 4. Migraine duration \> 6 months
• • 5. Without preventative treatment or with stable preventative treatment for migraine (no change in intervention in the last 6 months)
• Exclusion Criteria for the healthy group:
• * Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
• • 1. Diagnosis of any chronic pain syndrome
• • 2. Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder
• • 3. Taking pain or psychiatric medications regularly
• • 4. Having an MRI contraindication such as metal in the body or claustrophobia
• • 5. Not able to understand and communicate in English
• • Exclusion Criteria for the migraine group
• * Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
• • 1. Diagnosis of any chronic pain syndrome other than migraine
• • 2. Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder
• • 3. Having an MRI contraindication such as metal in the body or claustrophobia
• • 4. Not able to understand and communicate in English

Trial Officials