Effects of Increasing Mean Arterial Pressure on Renal Function in Patients with Shock and with Elevated Central Venous Pressure

Launched by UNIVERSITY HOSPITAL, ANGERS · Dec 14, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how increasing blood pressure affects kidney function in patients who are experiencing shock, which is a serious condition where the body doesn't get enough blood flow. Specifically, the study wants to see if raising the average blood pressure can help improve kidney performance in patients who also have high pressure in their veins. The trial is currently recruiting adult participants aged 18 and older who are experiencing low blood pressure and require medication to support their heart function.

To be eligible for this study, patients need to have certain conditions, such as needing medication like norepinephrine to manage their blood pressure and having a specific level of pressure in their veins. However, there are some important exclusions, like not being able to participate if a patient is not producing urine or if they are pregnant. Participants in this trial will be closely monitored, and their kidney function will be assessed to understand the effects of the treatment. This research aims to find better ways to help patients in critical conditions, so their kidneys can function properly while they recover.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (≥ 18 years old )
• • Arterial hypotension requiring the etablishment of catecholamines
• • Norepinephrine dose ⩾ 0.1µg/kg/min at the inclusion
• • High central venous pressure ≥ 12mmHg
• • Cardiac output monitoring (PICCO or Swan Ganz)
• Exclusion Criteria:
• • Anuria
• • Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \<7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \> 40 mmol/l)
• • Pregnant, lactating or parturient woman
• • Patient deprived of liberty by judicial or administrative decision
• • Patient with psychiatric compulsory care
• • Patient subject to legal protection measures
• • Patients with do-no-reanimate order or withdrawal of life sustaining support