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Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure

Launched by UNIVERSITY HOSPITAL, ANGERS · Dec 14, 2022

Trial Information

Current as of February 05, 2025

Not yet recruiting

Keywords

Mean Arterial Pressure Central Venous Pressure Renal Function

ClinConnect Summary

Current recommandation for mean arterial pressure (MAP) target is 65 mmHg for septic shock, but optimal target to prevent acute renal failure (ARF) remains unknown.

High central venous pressure (CVP) can lead to acute renal failure through venous congestion , and is associated with acute renal failure in intensive care unit.

A decrease of renal perfusion pressure, defined by MAP - CVP, has been shown to be associated with risk of acute renal failure.

The main objective of this trial is to evaluate if an optimisation of renal perfusion pressure, by a higher MAP when CVP is high (≥ 12 cmH2...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adult patients (≥ 18 years old )
  • Arterial hypotension requiring the etablishment of catecholamines
  • Norepinephrine dose ⩾ 0.1µg/kg/min at the inclusion
  • High central venous pressure ≥ 12mmHg
  • Cardiac output monitoring (PICCO or Swan Ganz)
  • Exclusion Criteria:
  • Anuria
  • Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \<7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \> 40 mmol/l)
  • Pregnant, lactating or parturient woman
  • Patient deprived of liberty by judicial or administrative decision
  • Patient with psychiatric compulsory care
  • Patient subject to legal protection measures
  • Patients with do-no-reanimate order or withdrawal of life sustaining support

Trial Officials

Pierre ASFAR, MD PhD

Principal Investigator

Angers University Hospital

About University Hospital, Angers

The University Hospital of Angers is a leading academic medical institution dedicated to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital leverages its multidisciplinary expertise and state-of-the-art facilities to investigate new therapeutic approaches and improve patient outcomes. Committed to excellence in patient care and medical education, the University Hospital of Angers collaborates with a network of researchers and healthcare professionals to facilitate groundbreaking studies across various medical fields, ensuring rigorous adherence to ethical standards and regulatory compliance. Through its clinical trial initiatives, the institution aims to contribute significantly to the advancement of medical knowledge and the development of effective treatments.

Locations

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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