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Histological Profiles of Lung Allograft Transbronchial Biopsies and Clinical Outcomes After Lung Transplantation

Launched by PARIS TRANSLATIONAL RESEARCH CENTER FOR ORGAN TRANSPLANTATION · Dec 8, 2022

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Trial Information

Current as of February 05, 2025

Completed

Keywords

Lung Transplantation Rejection Transbronchial Biopsy Donor Specific Antibody Cluster Analysis

ClinConnect Summary

SCIENTIFIC JUSTIFICATION:

With more than three million deaths per year, the chronic obstructive pulmonary disease is currently the third cause of mortality worldwide , and contributes to the growing number of individuals with end-stage lung disease, which is now a major issue for world public health. Overall, for individuals with end-stage lung disease, lung transplantation (LTx) is the only treatment able to increase patient survival and quality of life, with more than 4,500 lung transplantations performed each year.

Despite major progresses made in the last decade regarding organ preser...

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ALL

Eligibility criteria

  • Inclusion Criteria:
  • • i) age greater than 18 years,
  • • ii) single or bilateral lung transplantation,
  • • iii) having at least one transbronchial biopsy available for analysis
  • • iv) consent their clinical data to be used for research
  • Exclusion Criteria:
  • • • Biopsies with at least one missing value in the standardized clinical report were excluded

About Paris Translational Research Center For Organ Transplantation

The Paris Translational Research Center for Organ Transplantation is a leading clinical trial sponsor dedicated to advancing the field of organ transplantation through innovative research and collaborative efforts. Committed to bridging the gap between laboratory discoveries and clinical applications, the center focuses on improving transplant outcomes, enhancing patient care, and developing novel therapeutic strategies. With a multidisciplinary team of experts, the center fosters a rigorous research environment that promotes scientific excellence and ethical standards, ultimately aiming to transform the landscape of organ transplantation and provide hope for patients in need of lifesaving procedures.

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