Trials
Search / Trial NCT05655260

PErsonalized TReatment for Endometrial Carcinoma

Launched by UNIVERSITY OF HELSINKI · Dec 8, 2022

Trial Information

Current as of January 17, 2025

Recruiting

Keywords

Endometrial Carcinoma Molecular Classification Adjuvant Therapy

ClinConnect Summary

This clinical trial is looking at different treatment options for women with early-stage endometrial cancer, specifically types that are considered high-risk for recurrence. The researchers want to see how well two main types of treatment work: one group of participants will receive chemotherapy, while another group will get a combination of chemotherapy and radiation. Additionally, they will compare two types of radiation therapy—vaginal brachytherapy and whole pelvic radiotherapy—based on specific cancer characteristics.

To be eligible for this trial, participants should be women aged 18 to 100 who have been diagnosed with stage I or II high-risk endometrial cancer. They should have a good overall health status and should not have had certain previous cancers or treatments that could interfere with the study. If you decide to participate, you’ll be closely monitored throughout the process and will contribute to important research that could help improve treatment for future patients with similar conditions.

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • Age 18 to 100 years
  • WHO performance status 0 to 2
  • Stage I-II molecular integrated high-intermediate or high-risk endometrial carcinoma
  • Exclusion Criteria:
  • Age \<18 years or \>100 years
  • WHO performance status \>2
  • Uterine sarcoma
  • A history of malignancy within 5 years
  • Previous pelvic radiotherapy
  • An interval of \>30 days between surgery and start of chemotherapy or \>8 weeks between surgery and start of radiotherapy (longer intervals may be permitted with investigator´s approval)

Trial Officials

Mikko Loukovaara

Principal Investigator

Helsinki University Central Hospital

About University Of Helsinki

The University of Helsinki, a prestigious institution in Finland, is dedicated to advancing health sciences through innovative research and clinical trials. With a strong emphasis on interdisciplinary collaboration, the university engages in cutting-edge studies that aim to improve patient outcomes and contribute to the global knowledge base in medicine. Its commitment to ethical standards and rigorous methodology ensures the integrity and reliability of its clinical research initiatives, making it a key player in the development of novel therapeutic strategies and healthcare solutions.

Locations

Helsinki, , Finland

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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