Effect of a Vaccination Against COVID-19 on Monocyte Production of Oxygenated Derivatives.

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES · Dec 15, 2022

Keywords

ClinConnect Summary

In this pandemic period, vaccination against SARSCoV- 2 is an essential weapon. However, the immune memory induced by current vaccines remains ephemeral, requiring early booster shots. It is primordial to improve this vaccine memory.

Recently it has been demonstrated that monocytes from certain individuals hospitalized for SARSCoV-2 infection spontaneously overproduced oxygenated derivatives (ROS) capable of inducing DNA damage in neighboring cells and T cell apoptosis (Kundura et al., 2022). In agreement with these observations, up to 50% of peripheral blood mononuclear cells (PBMC) from ...

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Eligibility criteria

• Inclusion Criteria:
• • Candidate for SARS-CoV-2 vaccination with an mRNA vaccine (Pfizer, Moderna).
• • Subject has given free and informed consent.
• • Subject who has signed the consent form.
• • Person affiliated to or beneficiary of a health insurance plan.
• Exclusion Criteria:
• • Patients under treatment with N-acetylcysteine or sartan.
• • Patients with a dysimmune pathology or immunosuppressive treatment.
• • Person infected with SARS-CoV-2 within 3 months prior to inclusion.
• • Person participating in a category 1 defined RIPH.
• • Subject in an exclusion period as determined by another study.
• • Person under court protection, guardianship or trusteeship.
• • Subject who is unable to give consent.
• • Subject for whom it is impossible to give clear information.
• • Pregnant or breastfeeding woman.