The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
Launched by ALEXANDRIA UNIVERSITY · Dec 15, 2022
Trial Information
Current as of February 05, 2025
Completed
Keywords
ClinConnect Summary
The main objective of this observational study is to recommend the most effective empiric topical antimicrobial therapy in microbial keratitis, according to the current local antimicrobial resistance data and the clinical outcomes of patients with bacterial, fungal, and mixed bacterial and fungal keratitis being treated with different empiric topical antibiotics and antifungal therapies.
In the study, test results of routinely performed culture and sensitivity on corneal scraping samples and on contact lenses in indicated severe, centrally located, and large ulcers are collected and analyz...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients diagnosed with bacterial keratitis either clinically or by culture.
- • Patients diagnosed with fungal keratitis either clinically or by culture.
- • Patients diagnosed with mixed bacterial and fungal keratitis either clinically or by culture.
- Exclusion Criteria:
- • Patients diagnosed with corneal abrasions and non-infectious corneal ulcers.
- • Patients diagnosed with acanthamoeba keratitis as a single causative agent.
- • Patients diagnosed with viral keratitis as a single causative agent.
- • Patients who are noncompliant to treatment.
Trial Officials
Nelly M Mohamed, PhD
Principal Investigator
Associate Professor of Microbiology and Immunology, Alexandria University
Tamer H Massoud, PhD
Principal Investigator
Associate Professor of Ophthalmology, Alexandria University
Noha A Hamdy, PhD
Principal Investigator
Assistant Professor of Clinical Pharmacy, Alexandria University
Amira A Nayel, PharmD
Principal Investigator
Master's student at the Department of Clinical Pharmacy and Pharmacy Practice, Alexandria University
About Alexandria University
Alexandria University, a leading academic institution in Egypt, is dedicated to advancing medical research and improving healthcare outcomes through innovative clinical trials. With a strong emphasis on collaboration and interdisciplinary approaches, the university leverages its extensive resources and expertise to conduct rigorous studies that address pressing health challenges. By fostering partnerships with healthcare professionals, industry leaders, and regulatory bodies, Alexandria University aims to contribute to the global body of medical knowledge and enhance the quality of patient care through evidence-based findings.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Alexandria, , Egypt
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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