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The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study

Launched by ALEXANDRIA UNIVERSITY · Dec 15, 2022

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Trial Information

Current as of January 22, 2025

Completed

Keywords

Microbial Keratitis Infectious Corneal Ulcer Bacterial Keratitis Fungal Keratitis Mycotic Keratitis Antibiogram Antimicrobial Resistance Culture Sensitivity Fortified Antibiotics Eye Drops Moxifloxacin Natamycin Voriconazole Prevalence Antifungal Eye Drops Bacteria Fungi Vancomycin Ceftazidime Gentamicin Mixed Bacterial And Fungal Keratitis

ClinConnect Summary

The main objective of this observational study is to recommend the most effective empiric topical antimicrobial therapy in microbial keratitis, according to the current local antimicrobial resistance data and the clinical outcomes of patients with bacterial, fungal, and mixed bacterial and fungal keratitis being treated with different empiric topical antibiotics and antifungal therapies.

In the study, test results of routinely performed culture and sensitivity on corneal scraping samples and on contact lenses in indicated severe, centrally located, and large ulcers are collected and analyz...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Patients diagnosed with bacterial keratitis either clinically or by culture.
  • • Patients diagnosed with fungal keratitis either clinically or by culture.
  • • Patients diagnosed with mixed bacterial and fungal keratitis either clinically or by culture.
  • Exclusion Criteria:
  • • Patients diagnosed with corneal abrasions and non-infectious corneal ulcers.
  • • Patients diagnosed with acanthamoeba keratitis as a single causative agent.
  • • Patients diagnosed with viral keratitis as a single causative agent.
  • • Patients who are noncompliant to treatment.

Trial Officials

Nelly M Mohamed, PhD

Principal Investigator

Associate Professor of Microbiology and Immunology, Alexandria University

Tamer H Massoud, PhD

Principal Investigator

Associate Professor of Ophthalmology, Alexandria University

Noha A Hamdy, PhD

Principal Investigator

Assistant Professor of Clinical Pharmacy, Alexandria University

Amira A Nayel, PharmD

Principal Investigator

Master's student at the Department of Clinical Pharmacy and Pharmacy Practice, Alexandria University

About Alexandria University

Alexandria University, a leading academic institution in Egypt, is dedicated to advancing medical research and improving healthcare outcomes through innovative clinical trials. With a strong emphasis on collaboration and interdisciplinary approaches, the university leverages its extensive resources and expertise to conduct rigorous studies that address pressing health challenges. By fostering partnerships with healthcare professionals, industry leaders, and regulatory bodies, Alexandria University aims to contribute to the global body of medical knowledge and enhance the quality of patient care through evidence-based findings.

Locations

Alexandria, , Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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