Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy
Launched by AIN SHAMS UNIVERSITY · Dec 10, 2022
Trial Information
Current as of January 14, 2025
Completed
Keywords
ClinConnect Summary
Periodontitis is a multifactorial inflammatory disease that is triggered by the accumulation of oral biofilm on the tooth surface, leading to progressive destruction of the periodontal supporting tissues including loss of clinical attachment level, alveolar bone resorption, and formation of periodontal pockets due to apical migration of junctional epithelium. It is characterized by microbially-associated, host-mediated inflammation that leads to loss of periodontal apparatus. The formation of a bacterial biofilm begins with gingival inflammation; however, the initiation and progression of p...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients with ages ranging from 25 to 50 years old.
- • Localized periodontitis, probing depth ≥5 mm. Less than 30% of teeth are involved.
- • Both genders.
- • Patients must be able to return for the recall visits and agreed to sign the written consent after a full explanation of the study.
- • Systemically free according to the American Society of Anesthesiologists (ASA I).
- Exclusion Criteria:
- • Smokers
- • Pregnant and lactating women or oral contraceptive usage
- • Prisoners or abused individuals
- • Unwilling patients to perform oral hygiene measures of plaque control.
- • Patients with a history of allergy against any components of the two materials.
- • Previous Periodontal treatment or any use of antibiotic/anti-inflammatory drugs within the last 6 months before the initiation of the study.
Trial Officials
Hala Abuelela, Professor
Study Director
Professor of Oral medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt
Olfat Shaker, Professor
Study Director
Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo university, Egypt
Dina Osman, Professor
Study Director
Professor of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Girls), Al Azhar university, Egypt
Suzan Sarhan, PHD
Study Director
Lecturer of Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt
About Ain Shams University
Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, , Egypt
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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