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Search / Trial NCT05657015

Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy

Launched by AIN SHAMS UNIVERSITY · Dec 10, 2022

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Trial Information

Current as of January 14, 2025

Completed

Keywords

In Situ Gel High Performance Thic Layer Chromatography Local Drug Delivery

ClinConnect Summary

Periodontitis is a multifactorial inflammatory disease that is triggered by the accumulation of oral biofilm on the tooth surface, leading to progressive destruction of the periodontal supporting tissues including loss of clinical attachment level, alveolar bone resorption, and formation of periodontal pockets due to apical migration of junctional epithelium. It is characterized by microbially-associated, host-mediated inflammation that leads to loss of periodontal apparatus. The formation of a bacterial biofilm begins with gingival inflammation; however, the initiation and progression of p...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Patients with ages ranging from 25 to 50 years old.
  • • Localized periodontitis, probing depth ≥5 mm. Less than 30% of teeth are involved.
  • • Both genders.
  • • Patients must be able to return for the recall visits and agreed to sign the written consent after a full explanation of the study.
  • • Systemically free according to the American Society of Anesthesiologists (ASA I).
  • Exclusion Criteria:
  • • Smokers
  • • Pregnant and lactating women or oral contraceptive usage
  • • Prisoners or abused individuals
  • • Unwilling patients to perform oral hygiene measures of plaque control.
  • • Patients with a history of allergy against any components of the two materials.
  • • Previous Periodontal treatment or any use of antibiotic/anti-inflammatory drugs within the last 6 months before the initiation of the study.

Trial Officials

Hala Abuelela, Professor

Study Director

Professor of Oral medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt

Olfat Shaker, Professor

Study Director

Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo university, Egypt

Dina Osman, Professor

Study Director

Professor of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Girls), Al Azhar university, Egypt

Suzan Sarhan, PHD

Study Director

Lecturer of Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt

About Ain Shams University

Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.

Locations

Cairo, , Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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