Utility of CYP2D6 Genotyping to Improve the Efficacy and Safety of Tramadol

Launched by FUNDACIÓN DE INVESTIGACIÓN BIOMÉDICA - HOSPITAL UNIVERSITARIO DE LA PRINCESA · Dec 11, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how genetic testing (specifically looking at a gene called CYP2D6) can help doctors better prescribe tramadol, a pain medication, for patients recovering from surgery. The goal is to see if knowing a patient's genetic makeup can improve how well tramadol works for pain relief while also reducing the chances of side effects. This study is particularly focused on patients who are having at least two impacted wisdom teeth removed under local anesthesia.

To join the study, participants need to be at least 18 years old and scheduled for this type of dental surgery. They should not be taking certain medications that could interfere with tramadol, nor have other health issues that could complicate their treatment. Those who take part will provide consent and then be monitored during their recovery to see how effective the medication is and if they experience any side effects. The trial is currently recruiting participants, and it aims to improve pain management practices based on individual genetics.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men or women over 18 years of age.
• • Patients scheduled for outpatient surgical extraction, under local anesthesia, of at least two impacted third molars, at least one of which will require bone removal.
• • Patients who agree to participate in the study and give written consent.
• Exclusion Criteria:
• • Patients under treatment with other drugs that can inhibit CYP2D6, or are contraindicated in combination with tramadol or dexketoprofen.
• • Patients on treatment with bisphosphonates.
• • Patients who are receiving analgesic treatment before the operation, 24 hours prior to the operation. This criterion will be evaluated at the intervention visit.
• • Patients suffering from other uncontrolled diseases.
• • Pregnant or breastfeeding women.
• • Patients with contraindications for treatment with tramadol or dexketoprofen.