Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
Launched by OLATEC THERAPEUTICS LLC · Dec 13, 2022
Trial Information
Current as of July 23, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a medication called dapansutrile (OLT1177®) to see how well it works and how safe it is for people experiencing an acute gout flare, which is a sudden and painful attack of gout often affecting the joints. Gout is a type of arthritis that can cause severe pain, swelling, and redness in the affected area. The trial is currently looking for participants who are 18 years or older and have a confirmed diagnosis of gout, along with an active gout flare that started within the last four days.
If you decide to participate, you will need to provide written consent and meet certain health criteria. For example, you should not have inflammatory arthritis other than gout or a history of severe kidney problems. Throughout the trial, you will be closely monitored, and you’ll have the chance to share your experience with the medication. This study aims to improve our understanding of how to better manage gout flares, which can be very painful for those who suffer from this condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Male and female subjects age 18 or older
- * Clinical diagnosis of gout according to the 2015 ACR/EULAR Gout Classification Criteria:
- • A) Diagnosis of gout must be confirmed in the target joint as indicated by either the presence of monosodium urate (MSU) crystals by microscopic evaluation of synovial fluid from the target joint or bursa OR by imaging evidence of urate deposition in the target joint or bursa at the Screening/Baseline Visit/Study Day 1, or
- • B) Documented history in the target joint or bursa ; or documented history of 2 or more gout flares in the previous 18 months
- • Confirmation of a gout flare in the target joint that began within 96 hours prior to the Screening/Baseline Visit
- • Provide written informed consent and understand and comply with all trial requirements
- Exclusion Criteria:
- • Presence of any palpable and visible tophi by physical examination
- • Has ≥ 4 joints with an acute gout flare at Screening/Baseline
- • Presence of active rheumatoid arthritis or other acute inflammatory arthritis
- • Evidence/suspicion of infectious/septic arthritis
- • Clinically significant general pain or non-gout-related joint pain that would interfere with the subject's ability to accurately assess pain in the target joint
- • Known diagnosis of chronic kidney disease or known history of renal impairment
- • Positive test for severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infection, if tested, within 4 weeks of the Screening/Baseline
- • Active malignancy or recent malignancy with any systemic anti-cancer treatment
- • Has a hypersensitivity or allergy to OLT1177® or other drugs in its class
- • Hypersensitivity or allergy to paracetamol/acetaminophen
- • Use of any prohibited concomitant medications/therapies over the periods defined in the protocol or planned use of any prohibited concomitant medications/therapies during the Treatment Period (including the use of paracetamol/acetaminophen within 4 hours prior to the Screening/Baseline Visit or other pain medications within 12 hours prior to the Screening/ Baseline Visit
- • Use of any product containing paracetamol/acetaminophen within 4 hours prior to the Screening/Baseline Visit or planned use during the Treatment Period (with the exception of study-provided Rescue Medication \[paracetamol/acetaminophen\], which is permitted after completion of the first target joint pain assessment on Study Day 4
About Olatec Therapeutics Llc
Olatec Therapeutics LLC is a biopharmaceutical company dedicated to the development of innovative therapeutics aimed at addressing unmet medical needs in various disease areas. With a focus on leveraging advanced scientific research and robust clinical methodologies, Olatec is committed to discovering and bringing to market novel treatments that enhance patient outcomes and quality of life. The company is driven by a mission to improve healthcare through evidence-based solutions and is actively engaged in clinical trials to evaluate the safety and efficacy of its therapeutic candidates.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Spokane, Washington, United States
Barcelona, , Spain
Madrid, , Spain
Paris, , France
Missoula, Montana, United States
Venlo, , Netherlands
Afula, , Israel
Los Angeles, California, United States
Lomme, , France
Maastricht, , Netherlands
Madrid, , Spain
Haifa, , Israel
Chicago, Illinois, United States
New York, New York, United States
Ann Arbor, Michigan, United States
Duncansville, Pennsylvania, United States
Lexington, Kentucky, United States
Alicante, , Spain
Birmingham, Alabama, United States
Jacksonville, Florida, United States
Deland, Florida, United States
Miami, Florida, United States
New York, New York, United States
San Diego, California, United States
Tarzana, California, United States
Alicante, , Spain
Anchorage, Alaska, United States
Birmingham, Alabama, United States
Bothell, Washington, United States
Alicante, , Spain
Deland, Florida, United States
Thomasville, Georgia, United States
Amarillo, Texas, United States
Glendale, Arizona, United States
Mesa, Arizona, United States
El Cajon, California, United States
Lexington, California, United States
Los Angeles, California, United States
Summerville, California, United States
Tarzana, California, United States
Debary, Florida, United States
Chicago, Illinois, United States
Orland Park, Illinois, United States
Missoula, Montana, United States
Spokane, Washington, United States
Glendale, Arizona, United States
Mesa, Arizona, United States
Debary, Florida, United States
Jacksonville, Florida, United States
Tampa, Florida, United States
Gainesville, Georgia, United States
New York, New York, United States
Duncansville, Pennsylvania, United States
Summerville, South Carolina, United States
Amarillo, Texas, United States
Salt Lake City, Utah, United States
Rouen, , France
Amsterdam, , Netherlands
Bordeaux, , France
Orland Park, Illinois, United States
Ramat Gan, , Israel
Petah Tiqva, , Israel
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials