Ventral Capsulotomy for Intractable OCD

Launched by BUTLER HOSPITAL · Dec 12, 2022

Keywords

ClinConnect Summary

This study is exploring how a laser-assisted brain surgery called ventral capsulotomy affects people with severe obsessive-compulsive disorder (OCD). The researchers want to see how the surgery changes brain connections and whether those changes relate to improvements in OCD symptoms. They will track OCD symptoms with the Yale-Brown Obsessive-Compulsive Scale (YBOCS) at 12 and 24 months after surgery (higher YBOCS scores mean more severe symptoms). They’ll also look at mood and anxiety changes using the HDRS and HARS scales at 12 months.

Who can participate: adults aged 18 to 90 who are already approved to have capsulotomy for severe OCD at Butler Hospital in Providence, Rhode Island. The study plans to enroll about 50 people, and it uses a single-group design (everyone receives the same treatment; there’s no comparison group). The trial involves the surgical procedure (laser ventral capsulotomy) and several MRI scans to study brain structure and function, plus special cognitive tests related to the brain circuits involved in OCD. It is currently enrolling by invitation and is conducted by Butler Hospital with NIH collaboration.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who will be undergoing capsulotomy for severe OCD, as approved by the Butler Hospital Psychiatric Neurosurgery Committee