Characterization of Arrhythmia-induced Cardiomyopathy

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Dec 14, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a condition called arrhythmia-induced cardiomyopathy (AiCM), which is a type of heart problem that can happen when the heart beats irregularly. The goal of the study is to collect information from patients who may have this condition at the University Hospital Basel. Researchers want to understand how AiCM affects people and gather data that can help improve care for patients with this heart issue.

To participate in the trial, individuals should be between the ages of 65 and 74 and have a diagnosis or suspicion of AiCM. They must also agree to take part by signing a consent form. However, people who are younger than 18, have certain serious health conditions, or who do not wish to participate cannot join the study. Participants can expect to share their medical information and undergo assessments related to their heart health. It's important to note that this study is observational, meaning researchers will be collecting existing data rather than providing treatment.

Gender

ALL

Eligibility criteria

• • Prospective part
• Inclusion Criteria:
• • Diagnostic or suspicion of AiCM as presence of specified keyword in patient's file or as screened by colleagues of the internal medicine or cardiology clinics
• • Signed study consent
• Exclusion Criteria:
• • Patient's active refusal of the general consent of the University Hospital Basel
• • Age \<18 years old
• • Temporary exclusion criteria: Acute health condition such as myocardial infarction, patients presenting with a major trauma, a sepsis, patients shortly after cardiac surgery, and patients in shock (\>100 bpm, \<90 systolic BP, evidence of organ dysfunction).
• • Life expectancy \<1 year (palliative, terminal cancer)
• • Retrospective part
• Inclusion Criteria:
• • Patients with a reduced left-ventricular ejection fraction (LVEF ≤50%) or a reduction of 15% in the ejection fraction (EF) between two echocardiographies and a concomitant diagnosis of any arrhythmia likely to lead to AiCM within one year before or after diagnosis of the reduced LVEF from 2010-2021
• Exclusion Criteria:
• • Age \< 18 years old
• • Patient's active refusal of the general consent of the University Hospital Basel
• • Acute event clearly leading to an acutely reduced LVEF (massive type I myocardial infarction, cardiogenic shock from a coronary or myocardial etiology, septic shock leading to toxic myopathy, hypovolemic shock with reduced EF, cardiac arrest and/or need for resuscitation).
• • Patients with life expectancy \<1 year (palliative, terminal cancer)