Determinants of Vascular Leakage During Systemic Inflammatory Response Syndrome

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Dec 22, 2022

Keywords

ClinConnect Summary

This clinical trial, called SIRS-PERM, is studying the causes of capillary leakage during systemic inflammatory response syndrome (SIRS), a serious condition that can occur in critically ill patients. Researchers have identified specific proteins that may be linked to this leakage, which can worsen a patient's condition. By collecting blood and lung fluid samples from patients in two intensive care units, the study aims to see how these proteins relate to the severity of SIRS and the overall health of the patients.

To participate in this trial, patients aged 18 and older who are admitted to the European Georges-Pompidou Hospital or La Pitié-Salpêtrière ICU with symptoms of SIRS may be eligible. These symptoms include fever, fast heart rate, rapid breathing, or abnormal white blood cell counts. Participants can expect to provide samples at various times during their stay in the ICU, and their health will be monitored for 30 days. This research could lead to new ways to treat SIRS, focusing specifically on managing capillary leakage, which is a new approach in this field.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * All patients admitted in the European Georges Pompidou Hospital or La Pitié-Salpêtrière ICU, and exhibiting a systemic inflammatory response syndrome (SIRS), characterized by the following items:
• • Temperature \> 38°C ou \<36°C
• • Heart rate \>90/min
• • Respiratory rate \>20/min or PaCO2\<32mmHg
• • White cell count \> 12 000/mm3 ou \< 4 000/mm3
• Exclusion Criteria:
• • Age \<18 years
• • Decline to participate
• • Pregnancy
• • Cirrhosis Child-Pugh \> B
• • Denutrition with BMI\<15kg/m2
• • Nephrotic syndrome
• • Persons deprived of their liberty by a judicial or administrative decision (guardianship or tutelage measure)