REgistry of Pulmonary Arterial Hypertension Associated With CONNECTIVE Tissue Diseases (RECONNECTIVE)

Launched by INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN · Dec 19, 2022

Keywords

ClinConnect Summary

The RECONNECTIVE Registry is a study aimed at understanding pulmonary arterial hypertension (PAH) that is linked to connective tissue diseases, which are illnesses that affect the body's connective tissues, like joints and skin. This study will follow patients for at least five years to observe their health outcomes and how this specific type of high blood pressure affects their bodies. To participate, patients must have a confirmed diagnosis of Group I or Group IV pulmonary hypertension associated with connective tissue diseases, which means their condition has been medically verified through specific tests.

If you or a loved one has been diagnosed with a connective tissue disease and has pulmonary arterial hypertension, you might be eligible to join this study. Participants will undergo a procedure called right heart catheterization to confirm their condition and will be closely monitored over the years. This research is important because it will help improve treatment options and medical care for patients dealing with these challenging health issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Incident and prevalent patients diagnosed with Group I associated with Connective Tissue Diseases (CTD)
• • Incident and prevalent patients diagnosed with Group IV Pulmonary Arterial Hypertension (PAH) associated with Connective Tissue Diseases (CTD) with evidence of a chronic thromboembolic pulmonary disease by ventilation/perfusion pulmonary gammagraph or computed tomography pulmonary angiogram with at least three months of total anticoagulation therapy.
• • Patient diagnosed with a connective tissue disease according to the classification criteria of the American College of Rheumatology.
• • Precapillary pulmonary hypertension confirmed by right heart catheterization (RHC): Mean pulmonary arterial pressure (mPAP) \>20 mm Hg with a pulmonary arterial wedge pressure ≤ 15 mm Hg and Pulmonary vascular resistance (PVR) ≥ 2.0 Wood units
• Exclusion Criteria:
• • Patients who meet the criteria for another group of pulmonary hypertension (Groups II, III or V).