Effects of Multiple Mega-dose of Vitamin D3 Supplementation on Ameliorating Moderate to Severe Chronic Pain in Hemodialysis Patients

Launched by TAIPEI MEDICAL UNIVERSITY HOSPITAL · Dec 26, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how high doses of vitamin D3 might help reduce chronic pain in patients who are on hemodialysis, a treatment for kidney failure. Researchers believe that some patients experience more pain due to high levels of a hormone called parathyroid hormone (PTH). They will give 120 participants either a very high dose of vitamin D3 (576,000 IU once a week for four weeks) or a placebo (a dummy treatment) to see if it makes a difference in their pain levels, which will be measured using a simple pain scale.

To be eligible for this study, participants need to be at least 20 years old, currently on hemodialysis, and have high levels of PTH and chronic pain that scores at least 4 on the pain scale. They also need to agree to pay for two blood tests during the study to check their vitamin D levels. Participants will not be able to join if they have certain other health conditions or are already involved in another clinical trial. If you decide to take part, you'll be helping researchers learn more about managing pain in hemodialysis patients while receiving close monitoring throughout the study.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Haemodialysis subject ≥ 20 years old
• • 2. iPTH \> 250 pg/mL
• • 3. Chronic pain with visual analogue scale (VAS) score ≥ 4
• • 4. Voluntary to check serum 25(OH)D levels two times by his/her own payment during the study
• • 5. Sign the informed consent
• Exclusion Criteria:
• • 1. Used to participate in other clinical trials
• • 2. Chronic liver disease
• • 3. Sarcoidosis or multiple myeloma