Neural Pressure Support, Synchrony and Respiratory Muscle Unloading

Launched by KAROLINSKA INSTITUTET · Jan 2, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of support from a ventilator can help patients who have been on a breathing machine for more than 24 hours due to acute respiratory failure. The main goal is to understand how well patients can breathe with the help of the ventilator and how much work their muscles have to do. By using two different types of pressure support, researchers hope to find the best way to make patients feel more comfortable and recover faster.

To be eligible for this study, patients need to be intubated (having a tube placed in their throat to help them breathe) for over 24 hours and be in the process of weaning off the ventilator. However, individuals with certain health conditions, like bleeding disorders, unstable circulation, severe lung disease, fever, or those who are pregnant, cannot participate. If patients join the study, they will experience three different ventilator settings and be closely monitored to see how these changes affect their breathing and comfort levels.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Patients intubated for more than 24 hours in the weaning phase from the ventilator.
• Exclusion Criteria:
• • bleeding disorders (PK INR\>1,5 or APTT\>50s or platelet count \<50000/µL)
• • unstable circulation (requiring high vasopressor dose, for example Noradrenalin \>0,2µg/kg/min)
• • severe lung disease (PFI ≤ 13,3 kPa)
• • fever\> 38,5°C
• • pregnancy.